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H-2K中的单个遗传元件影响小鼠痘病毒感染中的T细胞抗病毒功能。

A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection.

作者信息

Kees U, Blanden R V

出版信息

J Exp Med. 1976 Feb 1;143(2):450-5. doi: 10.1084/jem.143.2.450.

DOI:10.1084/jem.143.2.450
PMID:55454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190124/
Abstract

Cell transfer experiments using mice with recombinant H-2 haplotypes were used to map the H-2 regions which must be shared by ectromelia-immune T-cell donors and virus-infected recipients for transfer of virus clearance mechanisms in the spleen. K- or D-region genes were necessary and sufficient; I-region genes were not involved. The remainder of the mouse genome could be varied widely without impairing the efficacy of T-cell antiviral function, provided either a K or a D region was shared in the donor-receipient combination. A mutation in a single genetic element of the K region of the H-2 complex abolished the antiviral effect of immune T-cell transfer in a donor-recipient combination which shared the K end.

摘要

利用具有重组H-2单倍型的小鼠进行细胞转移实验，以绘制出在脾脏中转移病毒清除机制时，脱脚病免疫T细胞供体和病毒感染受体必须共享的H-2区域。K区或D区基因是必需且足够的；I区基因未参与其中。小鼠基因组的其余部分可以有很大差异，而不会损害T细胞抗病毒功能的效力，只要在供体-受体组合中共享一个K区或一个D区即可。H-2复合体K区单个遗传元件的突变消除了在共享K端的供体-受体组合中免疫T细胞转移的抗病毒作用。

相似文献

1
A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection.H-2K中的单个遗传元件影响小鼠痘病毒感染中的T细胞抗病毒功能。
J Exp Med. 1976 Feb 1;143(2):450-5. doi: 10.1084/jem.143.2.450.
2
Regulation of the T-cell response to ectromelia virus infection. I. Feedback suppression by effector T cells.T细胞对埃可病毒感染反应的调节。I. 效应T细胞的反馈抑制
J Exp Med. 1976 Mar 1;143(3):469-81. doi: 10.1084/jem.143.3.469.
3
Effects of thymus-independent (B) cells and the H-2 gene complex on antiviral function of immune thymus-derived (T) cells.非胸腺依赖性（B）细胞和H-2基因复合体对免疫胸腺依赖性（T）细胞抗病毒功能的影响。
Aust J Exp Biol Med Sci. 1975 Jun;53(3):187-95. doi: 10.1038/icb.1975.19.
4
Specificity or affinity of cytotoxic T cells for self H-2K determinants apparently does not change between primary and secondary responses to ectromelia virus infection.细胞毒性T细胞对自身H-2K决定簇的特异性或亲和力在对痘苗病毒感染的初次和二次反应之间显然没有变化。
Aust J Exp Biol Med Sci. 1977 Feb;55(1):39-48. doi: 10.1038/icb.1977.4.
5
The cell-mediated immune response to ectromelia virus infection. I. Kinetics and characteristics of the primary effector T cell response in vivo.对埃可病毒感染的细胞介导免疫反应。I. 体内主要效应T细胞反应的动力学和特征。
Cell Immunol. 1976 Mar 15;22(2):271-82. doi: 10.1016/0008-8749(76)90029-0.
6
Cytotoxic T-cell response to Ectromelia virus-infected cells. Different H-2 requirements for triggering precursor T-cell induction or lysis by effector T cells defined by the BALB/c-H-2db mutation.针对感染痘苗病毒细胞的细胞毒性T细胞反应。由BALB/c-H-2db突变定义的效应T细胞触发前体T细胞诱导或裂解的不同H-2要求。
J Exp Med. 1977 Sep 1;146(3):869-80. doi: 10.1084/jem.146.3.869.
7
The cell-mediated immune response to ectromelia virus infection. Secondary response in vitro: specificity, nature of effector and responder cells and requirements for induction of antigenic changes in stimulator cells.针对痘苗病毒感染的细胞介导免疫反应。体外二次反应：特异性、效应细胞和反应细胞的性质以及刺激细胞诱导抗原变化的条件。
Aust J Exp Biol Med Sci. 1976 Jun;54(3):253-64.
8
The cell-mediated immune response to ectromelia virus infection. II. Secondary response in vitro and kinetics of memory T cell production in vivo.对痘苗病毒感染的细胞介导免疫反应。II. 体外二次反应及体内记忆性T细胞产生的动力学
Cell Immunol. 1976 Mar 15;22(2):283-96. doi: 10.1016/0008-8749(76)90030-7.
9
The effect of virus-immune serum on anti-viral cytotoxic T-cells in vivo and in vivo.病毒免疫血清在体内和体外对抗病毒细胞毒性T细胞的作用。 （注：原文中“in vivo and in vivo”表述有误，推测可能是“in vivo and in vitro”，译文按正确推测翻译）
J Gen Virol. 1979 Oct;45(1):73-80. doi: 10.1099/0022-1317-45-1-73.
10
Genetic factors in the stimulation of T cell responses against ectromelia virus-infected cells: role of H-2K, H-2D, and H-2I genes.刺激针对感染痘苗病毒细胞的T细胞反应中的遗传因素：H-2K、H-2D和H-2I基因的作用。
Aust J Exp Biol Med Sci. 1977 Oct;55(5):549-59. doi: 10.1038/icb.1977.54.

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The firstH- 2 mutant workshop.第一届 H-2 突变体研讨会。
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Importance of interferons in recovery from mousepox.干扰素在小鼠痘恢复过程中的重要性。
J Virol. 1993 Jul;67(7):4214-26. doi: 10.1128/JVI.67.7.4214-4226.1993.
8
Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes.主要组织相容性复合体限制的病毒免疫细胞毒性T淋巴细胞上的独特型
J Exp Med. 1981 Jun 1;153(6):1562-73. doi: 10.1084/jem.153.6.1562.
9
H-2-linked control of resistance to ectromelia virus infection in B10 congenic mice.B10同源小鼠中H-2连锁的抗痘苗病毒感染抗性控制。
Immunogenetics. 1983;18(3):255-65. doi: 10.1007/BF00952964.
10
Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice.决定C57BL小鼠对埃可病毒感染天然抗性的机制。
Infect Immun. 1983 Sep;41(3):1391-4. doi: 10.1128/iai.41.3.1391-1394.1983.

本文引用的文献

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Cellular immunity in host resistance to viral infections.宿主对病毒感染的细胞免疫。
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Immunotherapy with transfer factor.用转移因子进行免疫治疗。
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Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
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Macrophage activation in mice infected with ectromelia or lymphocytic choriomeningitis viruses.感染脱脚病病毒或淋巴细胞性脉络丛脑膜炎病毒的小鼠体内巨噬细胞的激活
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Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells.从全身性病毒感染中恢复的机制：鼠痘。II. 免疫淋巴细胞介导的恢复机制的被动转移
J Exp Med. 1971 May 1;133(5):1074-89. doi: 10.1084/jem.133.5.1074.
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Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum.从全身性病毒感染中恢复的机制：鼠痘。I. 抗胸腺细胞血清的作用
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T cell response to viral and bacterial infection.T细胞对病毒和细菌感染的反应。
Transplant Rev. 1974;19(0):56-88. doi: 10.1111/j.1600-065x.1974.tb00128.x.