Wright D J
Acta Trop. 1979 Jun;36(2):117-22.
Sera taken from mice given cyclophosphamide 75 min previously fails to substantially inhibit borrelial multiplication in vitro. Mice given cyclophosphamide were infected with Borrelia duttoni. Inability to demonstrate specific antibody in these mice did not prevent recovery from infection, resolution of the bacteraemia or appearance of an antigenic variant. Cyclophosphamide may delete suppressor lymphocytes allowing enhanced production of antibodies which may not only protect, but induce antigenic variation. Alternatively, recovery from infection may be unrelated to the immune response.
取自75分钟前注射环磷酰胺的小鼠的血清，在体外并不能显著抑制疏螺旋体的增殖。给小鼠注射环磷酰胺后，使其感染达顿疏螺旋体。在这些小鼠中无法检测到特异性抗体，但这并未阻止其从感染中恢复、菌血症消退或抗原变异体的出现。环磷酰胺可能会清除抑制性淋巴细胞，从而增强抗体的产生，这些抗体不仅可能起到保护作用，还可能诱导抗原变异。另外，从感染中恢复可能与免疫反应无关。
