氯丙嗪与人的噪音之间的行为拮抗作用。

Behavioural antagonism between chlorpromazine and noise in man.

作者信息

Hartley L, Couper-Smartt J, Henry T

出版信息

Psychopharmacology (Berl). 1977 Nov 24;55(1):97-102. doi: 10.1007/BF00432823.

Abstract

The effects of 25 mg and 75 mg of chlorpromazine and of 95 dBA of white noise were studied separately and together in 12 male human subjects. Performance, analysed by signal detection theory, showed that both noise and chlorpromazine applied separately caused impairment in similar ways. Suspended judgements were reduced and negative decisions correspondingly increased at low levels of evidence. When applied together, chlorpromazine and noise cancelled out each other's adverse effects. It is concluded that chlorpromazine is a specific behavioural antagonist of the stressful effects of noise.

摘要

分别对12名男性受试者研究了25毫克和75毫克氯丙嗪以及95分贝白噪声的作用，也研究了它们共同作用的效果。通过信号检测理论进行分析的表现显示，单独施加噪声和氯丙嗪都会以类似方式造成损害。在低证据水平下，保留判断减少，否定决策相应增加。当一起施加时，氯丙嗪和噪声相互抵消了彼此的不利影响。得出的结论是，氯丙嗪是噪声应激效应的一种特定行为拮抗剂。