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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sabri M I, Bone A H, Davison A N

Biochem J. 1974 Sep;142(3):499-507. doi: 10.1042/bj1420499.

Protein metabolism of myelin and other subcellular components from developing rat brain was studied for periods from 5h to 210 days after intraperitoneal injection of [(3)H]lysine and [(14)C]glucose. 2. Half-lives for total brain proteins (t(0.5)) were 27 days after [(3)H]lysine and 4 days after [(14)C]glucose injection. 3. Factors accounting for the difference in the turnover rates obtained with different precursors, and the problem of reutilization of the label were investigated. 4. The catabolism of purified myelin proteins was studied and the half-lives of individual myelin proteins were calculated. 5. Myelin basic proteins turned over at two different rates. Half-life of the fast component of myelin basic proteins was 19-22 days and the slow component exhibited a high degree of metabolic stability. 6. Proteolipid protein underwent slow turnover. High-molecular-weight Wolfgram (1966) proteins underwent (relatively) fast metabolism (t(0.5) of 17-22 days).

在腹腔注射[³H]赖氨酸和[¹⁴C]葡萄糖后5小时至210天的时间段内，研究了发育中大鼠脑内髓磷脂及其他亚细胞成分的蛋白质代谢。2. 注射[³H]赖氨酸后全脑蛋白质的半衰期（t₀.₅）为27天，注射[¹⁴C]葡萄糖后为4天。3. 研究了不同前体导致周转率差异的因素以及标记物再利用的问题。4. 研究了纯化髓磷脂蛋白的分解代谢，并计算了各个髓磷脂蛋白的半衰期。5. 髓磷脂碱性蛋白以两种不同速率周转。髓磷脂碱性蛋白快速成分的半衰期为19 - 22天，慢速成分表现出高度的代谢稳定性。6. 蛋白脂质蛋白周转缓慢。高分子量的沃尔夫拉姆（1966年）蛋白代谢（相对）较快（t₀.₅为17 - 22天）。

Sabri M I, Bone A H, Davison A N

Biochem J. 1974 Sep;142(3):499-507. doi: 10.1042/bj1420499.

Protein metabolism of myelin and other subcellular components from developing rat brain was studied for periods from 5h to 210 days after intraperitoneal injection of [(3)H]lysine and [(14)C]glucose. 2. Half-lives for total brain proteins (t(0.5)) were 27 days after [(3)H]lysine and 4 days after [(14)C]glucose injection. 3. Factors accounting for the difference in the turnover rates obtained with different precursors, and the problem of reutilization of the label were investigated. 4. The catabolism of purified myelin proteins was studied and the half-lives of individual myelin proteins were calculated. 5. Myelin basic proteins turned over at two different rates. Half-life of the fast component of myelin basic proteins was 19-22 days and the slow component exhibited a high degree of metabolic stability. 6. Proteolipid protein underwent slow turnover. High-molecular-weight Wolfgram (1966) proteins underwent (relatively) fast metabolism (t(0.5) of 17-22 days).

在腹腔注射[³H]赖氨酸和[¹⁴C]葡萄糖后5小时至210天的时间段内，研究了发育中大鼠脑内髓磷脂及其他亚细胞成分的蛋白质代谢。2. 注射[³H]赖氨酸后全脑蛋白质的半衰期（t₀.₅）为27天，注射[¹⁴C]葡萄糖后为4天。3. 研究了不同前体导致周转率差异的因素以及标记物再利用的问题。4. 研究了纯化髓磷脂蛋白的分解代谢，并计算了各个髓磷脂蛋白的半衰期。5. 髓磷脂碱性蛋白以两种不同速率周转。髓磷脂碱性蛋白快速成分的半衰期为19 - 22天，慢速成分表现出高度的代谢稳定性。6. 蛋白脂质蛋白周转缓慢。高分子量的沃尔夫拉姆（1966年）蛋白代谢（相对）较快（t₀.₅为17 - 22天）。