Clement J J, Song C W, Sand T T
Radiology. 1978 Feb;126(2):507-10. doi: 10.1148/126.2.507.
Oxygen consumption rates for mouse mastocytoma cells examined from 3 to 4 hours after x-irradiation with 250-2000 rads were consistently higher than controls. Cyclic fluctuations in oxygen consumption per cell were dose-dependent; peaks in consumption were generally greater in magnitude and occurred later in time with increasing dose. The cyclic response in consumption is probably due to cell synchronization effects, while the overall higher respiration rates of irradiated cells may reflect increased metabolic activity in response to radiation damage. Oxygen consumption rates for the total cell population were cyclic after 250 and 500 rads, but declined steadily after 1000 or 2000 rads; oxygen consumption rates tended to be lower than controls, especially 12-24 hours postirradiation. Differences between cellular and population oxygen consumption rates reflect changes in cell number after irradiation. It is suggested that postirradiation reoxygenation kinetics in solid tumors may result from changes in tumor oxygen demand.
用250 - 2000拉德的X射线照射后3至4小时检测的小鼠肥大细胞瘤细胞的耗氧率始终高于对照组。每个细胞耗氧量的周期性波动呈剂量依赖性；随着剂量增加，耗氧量峰值通常更大且出现时间更晚。耗氧量的周期性反应可能是由于细胞同步效应，而受照射细胞总体较高的呼吸速率可能反映了对辐射损伤的代谢活性增加。250和500拉德照射后，总细胞群体的耗氧率呈周期性，但1000或2000拉德照射后稳步下降；耗氧率往往低于对照组，尤其是照射后12 - 24小时。细胞和群体耗氧率之间的差异反映了照射后细胞数量的变化。有人提出实体瘤照射后再氧合动力学可能是由肿瘤需氧量的变化引起的。
