• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

传染性单核细胞增多症的免疫化学研究。III. 嗜异性抗体的分离与特性鉴定

Immunochemical studies of infectious mononucleosis. III. Isolation and characterization of heterophile antibodies.

作者信息

Fletcher M A, Lo T M

出版信息

Clin Exp Immunol. 1974 Apr;16(4):607-14.

PMID:4143250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553995/
Abstract

The heterophile antibody of infectious mononucleosis was isolated using an immunoabsorbent containing highly purified glycoprotein from horse erythrocyte membrane. Only the IgM fraction of this antibody agglutinated sheep erythrocytes or precipitated with the heterophile antigens from sheep, ox or horse red cells. The IgM antibody contained both κ and λ light chain determinants. The only reactivity which could be attributed to the IgG fraction of infectious mononucleosis serum was a slight degree of antigen binding by indirect radioimmunoelectrophoresis using I-labelled horse erythrocyte glycoprotein.

摘要

使用含有从马红细胞膜高度纯化的糖蛋白的免疫吸附剂分离传染性单核细胞增多症的嗜异性抗体。该抗体仅IgM部分能凝集绵羊红细胞或与来自绵羊、牛或马红细胞的嗜异性抗原发生沉淀反应。IgM抗体同时含有κ和λ轻链决定簇。传染性单核细胞增多症血清中IgG部分唯一可归因的反应性是使用I标记的马红细胞糖蛋白通过间接放射免疫电泳进行的轻微程度的抗原结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/8c60809c4beb/clinexpimmunol00277-0106-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/e11c4102c182/clinexpimmunol00277-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/a42253dafedb/clinexpimmunol00277-0105-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/5020cc675d26/clinexpimmunol00277-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/8c60809c4beb/clinexpimmunol00277-0106-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/e11c4102c182/clinexpimmunol00277-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/a42253dafedb/clinexpimmunol00277-0105-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/5020cc675d26/clinexpimmunol00277-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e6f/1553995/8c60809c4beb/clinexpimmunol00277-0106-b.jpg

相似文献

1
Immunochemical studies of infectious mononucleosis. III. Isolation and characterization of heterophile antibodies.传染性单核细胞增多症的免疫化学研究。III. 嗜异性抗体的分离与特性鉴定
Clin Exp Immunol. 1974 Apr;16(4):607-14.
2
[Immunochemical quantification of human monoclonal components].[人单克隆成分的免疫化学定量分析]
Quad Sclavo Diagn. 1985 Sep;21(3):306-16.
3
Heterophile IgM, IgA, and IgE antibodies in infectious mononucleosis.传染性单核细胞增多症中的嗜异性IgM、IgA和IgE抗体。
J Med Virol. 1989 May;28(1):38-41. doi: 10.1002/jmv.1890280109.
4
An immunochemical evaluation for the identification and typing of monoclonal proteins.用于单克隆蛋白鉴定和分型的免疫化学评估。
Ann Clin Biochem. 1990 Jul;27 ( Pt 4):327-34. doi: 10.1177/000456329002700408.
5
[The proportion of kappa and lambda light chains among monotypic IgG and IgA].单克隆IgG和IgA中κ和λ轻链的比例
Srp Arh Celok Lek. 1986 Nov-Dec;114(11-12):991-9.
6
Studies on the significance of Epstein-Barr virus-specific IgM in human sera.
IARC Sci Publ (1971). 1975(11 Pt 2):59-62.
7
Medical and technical usefulness of measurement of kappa and lambda immunoglobulin light chains in serum with an M-component.血清中κ和λ免疫球蛋白轻链与M蛋白成分检测的医学及技术应用价值
J Clin Chem Clin Biochem. 1989 Aug;27(8):519-23.
8
[Reversed immunofixation. Practical realization and interpretation].[反向免疫固定法。实际操作与解读]
Arch Inst Pasteur Tunis. 1982 Jun-Sep;59(2-3):303-9.
9
[Monoclonal gammopathy and infectious mononucleosis].[单克隆丙种球蛋白病与传染性单核细胞增多症]
Presse Med. 1985 Feb 23;14(8):487.
10
Analytical study of salivary immunoglobulins in multiple myeloma.多发性骨髓瘤患者唾液免疫球蛋白的分析研究
Clin Exp Immunol. 1974 Jul;17(3):417-26.

引用本文的文献

1
An enzyme-linked immunosorbent assay (ELISA) for measurement of heterophile antibody.一种用于检测嗜异性抗体的酶联免疫吸附测定（ELISA）。
Yale J Biol Med. 1982 Sep-Dec;55(5-6):429-36.
2
Studies on the heterophile antibodies of infectious mononucleosis. I. Separation of four antibody populations, one of which contains lymphocytotoxic activity.传染性单核细胞增多症嗜异性抗体的研究。I. 四种抗体群的分离，其中一种具有淋巴细胞毒性活性。
Clin Exp Immunol. 1977 Dec;30(3):354-63.

本文引用的文献

1
IMMUNOCHEMICAL CHARACTERIZATION AND SEROLOGIC BEHAVIOR OF ANTIBODIES AGAINST RED CELLS IN INFECTIOUS MONONUCLEOSIS.传染性单核细胞增多症中抗红细胞抗体的免疫化学特性及血清学行为
J Lab Clin Med. 1964 Oct;64:529-39.
2
THE NATURE OF SHEEP CELL AGGLUTININS AND OX CELL HAEMOLYSINS RELATED TO MONONUCLEOSIS INFECTIOSA.与传染性单核细胞增多症相关的绵羊细胞凝集素和牛红细胞溶血素的性质
Acta Pathol Microbiol Scand. 1964;61:551-7. doi: 10.1111/apm.1964.61.4.551.
3
SHEEP ERYTHROCYTE AGGLUTININS AND BEEF ERYTHROCYTE HEMOLYSINS IN INFECTIOUS MONONUCLEOSIS SERUM.
传染性单核细胞增多症血清中的绵羊红细胞凝集素和牛肉红细胞溶血素
J Immunol. 1963 Dec;91:783-90.
4
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
5
High molecular weight antibodies.高分子量抗体。
Ann N Y Acad Sci. 1960 Jun 30;86:966-73. doi: 10.1111/j.1749-6632.1960.tb42853.x.
6
Agglutination in rheumatoid arthritis serum of sheep cells sensitized with hemolysin and infectious mononucleosis agglutinins.类风湿关节炎血清对用溶血素致敏的绵羊细胞和传染性单核细胞增多症凝集素的凝集作用。
J Immunol. 1960 Nov;85:523-9.
7
The thiobarbituric acid assay of sialic acids.唾液酸的硫代巴比妥酸测定法。
J Biol Chem. 1959 Aug;234(8):1971-5.
8
Destruction of some agglutinins but not of others by two sulfhydryl compounds.两种巯基化合物对某些凝集素的破坏作用以及对其他凝集素的无破坏作用。
Acta Pathol Microbiol Scand. 1958;43(3):305-9. doi: 10.1111/j.1699-0463.1958.tb04899.x.
9
Observations on the ox cell haemolysins in human serum.关于人血清中牛细胞溶血素的观察
Clin Exp Immunol. 1967 May;2(3):285-93.
10
Immunochemical studies of infectious mononucleosis. II. Sodium dodecyl sulfate gel electrophoresis of membrane glycoprotein antigens.
Biochim Biophys Acta. 1972 Aug 31;278(1):163-74. doi: 10.1016/0005-2795(72)90118-3.