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[使用氯硝西泮对抗癫痫持续状态和慢性局灶性癫痫进行抗惊厥治疗期间的电临床相关性]

[Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam].

作者信息

Bücking P H

出版信息

Schweiz Arch Neurol Neurochir Psychiatr. 1977;121(2):187-205.

PMID:414352
Abstract

Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results. Severe etiologies in status were common. Therapy of partial and secondarily generalized convulsion is favoured. 18 patients with epilepsies of similar classification were treated by long term oral administration with inconstant results. Spatio-temporal and dose related profiles of convulsive and electroencephalographic desactivation are demonstrated. Signs of secondary generalisation were abolished first whereas focal signs turned out more resistent proved by repeated EEG recordings. Hypnotic effect as constituent or not in parenteral status therapy is discussed.

摘要

氯硝西泮通过静脉途径用于22例癫痫持续状态,效果特别好。癫痫持续状态的严重病因很常见。倾向于治疗部分性和继发性全身性惊厥。18例分类相似的癫痫患者接受长期口服治疗,效果不一。展示了惊厥和脑电图失活的时空及剂量相关特征。继发性全身性发作的体征首先消失,而局灶性体征经多次脑电图记录证明更具抗性。讨论了催眠作用在非肠道癫痫持续状态治疗中是否作为组成部分。

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