Congdon P J, Forsythe W I
Epilepsia. 1980 Feb;21(1):97-102. doi: 10.1111/j.1528-1157.1980.tb04049.x.
Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril). Status was promptly stopped in each instance with between 0.25 to 0.75 mg clonazepam. In 6 children who had a further episode of status epilepticus, diazepam 0.25 to 0.75 mg/kg was given. A comparison of their relative efficacy showed that in each case clonazepam had a more prolonged action. No serious side effects occurred and it was felt that i.v. clonazepam, because of its more prolonged action, could be the drug of choice in controlling status epilepticus.
17名发生癫痫持续状态的儿童(年龄范围为2周龄至15岁)接受了静脉注射氯硝西泮(利福全)治疗。在每例患儿中,均迅速用0.25至0.75毫克氯硝西泮终止了癫痫状态。6名再次发生癫痫持续状态的儿童接受了0.25至0.75毫克/千克的地西泮治疗。对它们相对疗效的比较显示,在每种情况下氯硝西泮的作用持续时间更长。未出现严重副作用,并且认为静脉注射氯硝西泮由于其作用持续时间更长,可能是控制癫痫持续状态的首选药物。