Rake M O, Flute P T, Shilkin K B, Lewis M L, Winch J, Williams R
Lancet. 1971 Dec 4;2(7736):1215-8. doi: 10.1016/s0140-6736(71)90540-x.
Four consecutive patients, three with fulminant hepatic failure and one with a severe relapse of serum hepatitis, who showed evidence of intravascular coagulation, were treated intensively with heparin and fresh frozen plasma. Rapid correction of the coagulation disturbance was achieved, and all four patients recovered completely. The necessity for starting such treatment early in the course of the disease and before the onset of major gastrointestinal bleeding is stressed, and it is suggested that intravascular coagulation may act as an intermediary in the pathogenesis of the hepatic necrosis.
连续4例患者，3例为暴发性肝衰竭，1例为血清性肝炎严重复发，均有血管内凝血证据，接受了肝素和新鲜冷冻血浆的强化治疗。凝血紊乱迅速得到纠正，所有4例患者均完全康复。强调了在疾病过程早期且在发生严重胃肠道出血之前开始这种治疗的必要性，并提示血管内凝血可能在肝坏死的发病机制中起中介作用。
