Ogunmekan D A
Tubercle. 1977 Dec;58(4):201-5. doi: 10.1016/0041-3879(77)90044-7.
3505 school children aged 6 to 15 years were tested with PPDS and at the same time one of the following tuberculins, namely, PPDG, PPDPL, PPDA, PPDF and PPDY. The tuberculins were prepared from human tubercle bacillus, the Gause organism, M. marinum, M. avium, M. fortuitum and M. kansasii respectively. PPDY, PPDA and PPDG gave more reactions of greater than 2 mm induration than did PPDS. Furthermore, tests with PPDY, PPDA, PPDG and PPDPL showed a significant proportion of children with reactions of 10 mm or more, suggesting that many of them had been sensitized to these antigens, particularly in the older age groups. The tuberculin sensitivity profile of these children resembled that found for a small community in Georgia, U.S.A., which had been studied previously. The profile also resembled that of guinea pigs which had been experimentally infected with the Gause organism. This supports the conclusion that a high proportion of these children had past or present infection with either the Gause organism or antigenically related mycobacteria. Finally, PPDS gave the highest percentage of children who had reactions greater than 10 mm. It is suggested that 10 mm might be a useful size of induration to divide opportunist mycobacterial infection from infection by M. tuberculosis in Lagos.
对3505名6至15岁的学童进行了PPDS检测，同时还检测了以下结核菌素之一，即PPDG、PPDPL、PPDA、PPDF和PPDY。这些结核菌素分别由人结核杆菌、高斯氏菌、海分枝杆菌、鸟分枝杆菌、偶然分枝杆菌和堪萨斯分枝杆菌制备。与PPDS相比，PPDY、PPDA和PPDG引起的硬结大于2毫米的反应更多。此外，用PPDY、PPDA、PPDG和PPDPL进行的检测显示，有相当比例的儿童硬结反应为10毫米或更大，这表明他们中的许多人已对这些抗原致敏，尤其是在年龄较大的组中。这些儿童的结核菌素敏感性特征与之前研究过的美国佐治亚州一个小社区的情况相似。该特征也与经高斯氏菌实验感染的豚鼠相似。这支持了这样的结论，即这些儿童中有很大比例曾感染过高斯氏菌或抗原相关的分枝杆菌，或者目前仍有感染。最后，PPDS检测中硬结大于10毫米的儿童比例最高。有人建议，在拉各斯，10毫米的硬结大小可能是区分机会性分枝杆菌感染和结核分枝杆菌感染的一个有用标准。
