细胞免疫的介质。VI. 抗有丝分裂药物长春碱对细胞抗感染抵抗力介质的影响。
The mediator of cellular immunity. VI. Effect of the antimitotic drug vinblastine on the mediator of cellular resistance to infection.
作者信息
McGregor D D, Logie P S
出版信息
J Exp Med. 1973 Mar 1;137(3):660-74. doi: 10.1084/jem.137.3.660.
The antimitotic drug vinblastine (Vbl) has a profound impact upon the specifically sensitized lymphocytes that transfer cellular resistance to Listeria monocytogenes. A 12-h pulse of the drug given to prospective donors during the first week of an immunizing Listeria infection inhibits the delivery of protective lymphocytes to the thoracic duct and their subsequent movement into an inflammatory exudate induced in the peritoneal cavity. The effect of Vbl is clearly related to its antimitotic activity, not to an effect on lymphocytes regardless of their position in the division cycle. This conclusion was drawn from an autoradiographic analysis of cells in the lymph of Vbl-treated rats and from failure of the drug to abrogate a known function of small lymphocytes, namely, their ability to initiate a graft-vs.-host reaction. The results imply that large lymphocytes, the rapidly proliferating cells in central lymph, are the principal effector cells responsible for transmitting resistance to L. monocytogenes and provide a plausible explanation for their rapid turnover and short circulating life-span.
抗有丝分裂药物长春碱（Vbl）对那些能传递对单核细胞增生李斯特菌细胞抗性的特异性致敏淋巴细胞有深远影响。在李斯特菌免疫感染的第一周，给潜在供体给予12小时的药物脉冲，会抑制保护性淋巴细胞输送到胸导管，以及它们随后进入腹膜腔诱导的炎性渗出物中的运动。Vbl的作用显然与其抗有丝分裂活性有关，而不是对处于分裂周期中任何位置的淋巴细胞的作用。这一结论来自对Vbl处理大鼠淋巴中细胞的放射自显影分析，以及该药物未能消除小淋巴细胞的已知功能，即它们引发移植物抗宿主反应的能力。结果表明，大淋巴细胞是中枢淋巴中快速增殖的细胞，是负责传递对单核细胞增生李斯特菌抗性的主要效应细胞，并为它们的快速更新和短循环寿命提供了合理的解释。
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