N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans.

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作者信息

Uehleke H, Tabarelli S

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1973;278(1):55-68. doi: 10.1007/BF00501863.

DOI:10.1007/BF00501863

PMID:4145470

Abstract

摘要

相似文献

N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans.

Naunyn Schmiedebergs Arch Pharmacol. 1973;278(1):55-68. doi: 10.1007/BF00501863.

N-hydroxylation of 4,4'-diaminodiphenylsulphone in liver microsomes and in vivo.

Xenobiotica. 1971 Jul-Oct;1(4):501-2. doi: 10.3109/00498257109041517.

Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.氨苯砜在人和实验动物体内的代谢研究：N-羟基代谢物的形成。

J Pharmacol Exp Ther. 1973 Oct;187(1):138-51.

Microsomal N-oxidation of dapson as a cause of methemoglobin formation in human red cells.

Am J Trop Med Hyg. 1972 May;21(3):322-31. doi: 10.4269/ajtmh.1972.21.322.

The role of cytochrome P-450 in the N-oxidation of individual amines.细胞色素P-450在单个胺类N-氧化中的作用。

Drug Metab Dispos. 1973 Jan-Feb;1(1):299-313.

The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes.西咪替丁预孵育对人肝微粒体中氨苯砜N-羟化作用的影响。

Br J Clin Pharmacol. 1991 Jul;32(1):120-3. doi: 10.1111/j.1365-2125.1991.tb05623.x.

Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.

Biochem Biophys Res Commun. 1974 Mar 25;57(2):426-33. doi: 10.1016/0006-291x(74)90948-6.

The monooxygenation of N-heptane by rat liver microsomes.大鼠肝脏微粒体对正庚烷的单加氧作用。

Biochim Biophys Acta. 1972 Dec 8;280(4):487-94. doi: 10.1016/0005-2760(72)90128-2.

[Hydroxylation of progesterone by rabbit liver microsomes. Changes in metabolite pattern after phenobarbital treatment of the animals].

Naunyn Schmiedebergs Arch Pharmakol. 1970;267(3):265-77.

Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated weith phenobarbital or 3-methylcholanthrene.在经苯巴比妥或3-甲基胆蒽处理的家兔肝脏微粒体中4-氯丙酰苯胺的ω-和（ω-1）-羟基化作用

Biochem Pharmacol. 1973 Oct 15;22(20):2575-80.

引用本文的文献

Dapsone in dermatology and beyond.氨苯砜在皮肤科及其他领域的应用。

Arch Dermatol Res. 2014 Mar;306(2):103-24. doi: 10.1007/s00403-013-1409-7. Epub 2013 Dec 6.

Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes.孕期疟疾的氨苯砜治疗：母婴结局

Drug Saf. 2004;27(9):633-48. doi: 10.2165/00002018-200427090-00002.

The pharmacokinetics of dapsone after oral administration to healthy volunteers.口服给予健康志愿者后氨苯砜的药代动力学。

Br J Clin Pharmacol. 1986 Oct;22(4):491-4. doi: 10.1111/j.1365-2125.1986.tb02924.x.

Clinical pharmacokinetics of dapsone.氨苯砜的临床药代动力学

Clin Pharmacokinet. 1986 Jul-Aug;11(4):299-315. doi: 10.2165/00003088-198611040-00003.

Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.氨苯砜被人肝微粒体酶生物激活为细胞毒性代谢物。

Br J Clin Pharmacol. 1989 Oct;28(4):389-95. doi: 10.1111/j.1365-2125.1989.tb03517.x.

An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system.使用两室体外测试系统研究代谢在氨苯砜诱导的高铁血红蛋白血症中的作用。

Br J Clin Pharmacol. 1990 Dec;30(6):829-38. doi: 10.1111/j.1365-2125.1990.tb05448.x.

Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.氨苯砜生物活化成细胞毒性代谢物：使用含人体组织的新型双室系统进行体外研究。

Br J Clin Pharmacol. 1990 Sep;30(3):417-26. doi: 10.1111/j.1365-2125.1990.tb03793.x.

Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone).服用氨苯砜（二（4-氨基苯基）砜）的疱疹样皮炎患者的血清血红素结合蛋白

Arch Dermatol Res (1975). 1975 Dec 31;254(3):225-32. doi: 10.1007/BF00557962.

Renal and biliary disposition of dapsone in the dog.氨苯砜在犬体内的肾脏和胆汁排泄情况。

Antimicrob Agents Chemother. 1975 Jun;7(6):816-24. doi: 10.1128/AAC.7.6.816.

Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物：治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况

Clin Pharmacokinet. 1976 Nov-Dec;1(6):426-43. doi: 10.2165/00003088-197601060-00003.

本文引用的文献

4-Amino-4'-hydroxylaminodiphenyl sulfone, its acetyl and D-glucosyl derivatives.4-氨基-4'-羟基氨基二苯砜及其乙酰基和D-葡萄糖基衍生物。

J Am Chem Soc. 1946 Aug;68:1438-42. doi: 10.1021/ja01212a013.

Studies in sulphone therapy.

Lepr Rev. 1952 Jan;23(1):4-29. doi: 10.5935/0305-7518.19520002.

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

Haemolytic anaemia during treatment of leprosy with diaminodiphenylsulphone by mouth.

Lancet. 1951 Jan 6;1(6645):21-2. doi: 10.1016/s0140-6736(51)93495-2.

4,4'-Diaminodiphenyl sulphone: solubility and distribution in blood.4,4'-二氨基二苯砜：在血液中的溶解度与分布

Biochem J. 1962 Jun;83(3):417-20. doi: 10.1042/bj0830417.

Metabolism and excretion of di(p-aminophenyl) sulphoxide in different animal species.

Br J Pharmacol Chemother. 1960 Mar;15(1):160-4. doi: 10.1111/j.1476-5381.1960.tb01225.x.

Dapsone in the treatment of dermatitis herpetiformis.

Lancet. 1955 Jun 11;268(6876):1201-2. doi: 10.1016/s0140-6736(55)90693-0.

Dapsone in dermatitis herpetiformis.氨苯砜治疗疱疹样皮炎。

Lancet. 1955 Jun 11;268(6876):1197-1200. doi: 10.1016/s0140-6736(55)90692-9.

DAPSONE-INDUCED HAEMOLYSIS.氨苯砜所致溶血

Br Med J. 1963 Sep 14;2(5358):662-4. doi: 10.1136/bmj.2.5358.662.

A preliminary report on the effect of diamino-diphenyl sulphone on malaria in northern Nigeria.关于二氨基二苯砜对尼日利亚北部疟疾影响的初步报告。

J Trop Med Hyg. 1960 Feb;63:25-7.

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