猪脑来源的两种还原型烟酰胺腺嘌呤二核苷酸磷酸连接醛还原酶的特性研究
The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain.
作者信息
Turner A J, Tipton K F
出版信息
Biochem J. 1972 Dec;130(3):765-72. doi: 10.1042/bj1300765.
Abstract
- NADPH-linked aldehyde reductase from pig, ox and rat brain exhibits non-linear reciprocal plots when partially purified enzyme preparations are studied. 2. In pig brain this non-linearity is due to the presence of two distinct aldehyde reductases, which can be separated by DEAE-cellulose chromatography. 3. These two enzymes can be distinguished by several criteria, including pH optima, Michaelis constants for substrates and their inhibitor sensitivity. 4. The probable role of these enzymes in the metabolism of the aldehydes derived from the biogenic amines is discussed.
摘要
- 对猪、牛和大鼠大脑中与NADPH相关的醛还原酶进行部分纯化后进行研究时，其呈现出非线性的双倒数图。2. 在猪脑中，这种非线性是由于存在两种不同的醛还原酶，它们可通过DEAE-纤维素色谱法分离。3. 这两种酶可通过多种标准加以区分，包括最适pH值、底物的米氏常数及其对抑制剂的敏感性。4. 讨论了这些酶在生物胺衍生醛类代谢中的可能作用。
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本文引用的文献
1
STUDIES ON THE BIOLOGICAL ACTIVITIES OF THE ALDEHYDES DERIVED FROM NOREPINEPHRINE, SEROTONIN, TRYPTAMINE AND HISTAMINE.
J Pharmacol Exp Ther. 1964 Mar;143:326-31.
2
The metabolism of acetaldehyde by the brain in vivo.大脑在体内对乙醛的代谢。
Biochem J. 1963 Jul;88(1):95-100. doi: 10.1042/bj0880095.
3
Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. I. Specificity and sigma-rho function.二磷酸吡啶核苷酸连接的醛脱氢酶。I. 特异性与西格玛-柔功能。
J Biol Chem. 1962 Feb;237:560-4.
4
The effect of disulfiram on the metabolism of normetanephrine-1-14C in the guinea pig.
Biochem Pharmacol. 1960 Jul;3:333-4. doi: 10.1016/0006-2952(60)90100-3.
5
A micro biuret method for protein determination; determination of total protein in cerebrospinal fluid.一种用于蛋白质测定的微量双缩脲法；脑脊液中总蛋白的测定
Scand J Clin Lab Invest. 1953;5(3):218-22. doi: 10.3109/00365515309094189.
6
Amine oxidase and amine metabolism.胺氧化酶与胺代谢
Pharmacol Rev. 1952 Dec;4(4):415-58.
7
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9
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