Fitch W, Jones J V, Graham D I, MacKenzie E T, Harper A M
Br J Anaesth. 1978 Feb;50(2):119-25. doi: 10.1093/bja/50.2.119.
The effect of graded, progressive hypotension on the autoregulation of cerebral blood flow was studied in anaesthetized baboons with experimental renovascular hypertension. Graded hypotension was induced over a period of 5-6 h by the administration of increasing concentrations of halothane. In these chronically hypertensive animals cerebral blood flow remained constant until the mean arterial pressure had decreased to approximately 90 mm Hg. At mean arterial pressures of less than this value cerebral blood flow was pressure passive. At the completion of the investigation the brains were fixed by perfusion and submitted to neuropathological examination. Evidence of chronic hypertension and of ischaemic brain damage was found in every animal.
在患有实验性肾血管性高血压的麻醉狒狒中，研究了分级、渐进性低血压对脑血流自动调节的影响。通过给予递增浓度的氟烷，在5 - 6小时内诱导出分级低血压。在这些慢性高血压动物中，脑血流保持恒定，直到平均动脉压降至约90毫米汞柱。在低于该值的平均动脉压下，脑血流呈压力被动性。在研究结束时，通过灌注固定大脑并进行神经病理学检查。在每只动物中均发现了慢性高血压和缺血性脑损伤的证据。
