Fitch W, Ferguson G G, Sengupta D, Garibi J, Harper A M
J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):1014-22. doi: 10.1136/jnnp.39.10.1014.
The effect of graded, progressive hypotension on the autoregulation of cerebral blood flow was studied in anaesthetised baboons. Progressive hypotension was produced over a period of four to five hours, either by graded haemorrhage or by the administration of increasing concentrations of hypotensive drugs. During haemorrhagic hypotension autoregulation was maintained until the mean arterial pressure had decreased to 65% of its baseline value, below which cerebral blood flow was pressure passive. In those animals subjected to drug-induced hypotension, autoregulation persisted to lower levels of mean arterial pressure (35-40% of baseline). It is postulated that under conditions of haemorrhagic hypotension, constriction of the extraparenchymal cerebral vessels in response to sympathetic stimulation decreases the possible range of autoregulation in the anaesthetised baboon.
在麻醉的狒狒身上研究了分级渐进性低血压对脑血流量自动调节的影响。通过分级出血或给予浓度递增的降压药物，在四到五个小时内产生渐进性低血压。在出血性低血压期间，自动调节功能得以维持，直到平均动脉压降至其基线值的65%，低于此值时脑血流量呈压力被动状态。在那些接受药物诱导性低血压的动物中，自动调节功能持续到平均动脉压更低的水平（基线的35%-40%）。据推测，在出血性低血压的情况下，对交感神经刺激作出反应的脑实质外血管收缩会减小麻醉狒狒的自动调节可能范围。
