Jones J V, Fitch W, MacKenzie E T, Strandgaard S, Harper A M
Circ Res. 1976 Oct;39(4):555-7. doi: 10.1161/01.res.39.4.555.
The effect of chronic renovascular hypertension on the autoregulation of cerebral blood flow was studied in anesthetized baboons. Cerebral blood flow was measured by the intracarotid 133Xe clearance method. Six baboons with renal hypertension of 8-12 weeks' duration were compared with six normotensive controls. The lower limit of autoregulation was determined following controlled hemorrhage. In the initially normotensive baboons, cerebral blood flow remained constant until mean arterial pressure had decreased to the range of 45-59 mm Hg. Thereafter, cerebral blood flow decreased with each further decrease in mean arterial pressure. In the chronically hypertensive baboons cerebral blood flow autoregulated until the mean arterial pressure had decreased to the range of 75-89 mm Hg. Therefore, the lower limit of autoregulation of cerebral blood flow was shifted to higher absolute levels of mean arterial pressure in baboons with chronic renovascular hypertension presumably due to adaptive changes in the cerebral circulation.
在麻醉的狒狒身上研究了慢性肾血管性高血压对脑血流自动调节的影响。采用颈内动脉133Xe清除法测量脑血流。将6只患有8 - 12周持续性肾性高血压的狒狒与6只血压正常的对照动物进行比较。在控制性出血后确定自动调节的下限。在最初血压正常的狒狒中，脑血流保持恒定，直到平均动脉压降至45 - 59毫米汞柱范围。此后，随着平均动脉压的进一步降低，脑血流减少。在慢性高血压狒狒中，脑血流自动调节，直到平均动脉压降至75 - 89毫米汞柱范围。因此，慢性肾血管性高血压狒狒脑血流自动调节的下限转移到了更高的平均动脉压绝对值水平，这可能是由于脑循环的适应性变化所致。
