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The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by adrenaline, ouabain and Mn++.大鼠脑组织匀浆中腺苷酸环化酶与其他利用ATP的酶及磷酸二酯酶活性的关系；肾上腺素、哇巴因和Mn++刺激环磷酸腺苷积累的机制。
Br J Pharmacol. 1973 Jul;48(3):516-26. doi: 10.1111/j.1476-5381.1973.tb08358.x.
2
The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by NaF.大鼠脑组织匀浆中腺苷酸环化酶与其他利用ATP的酶及磷酸二酯酶活性的关系；氟化钠刺激环磷酸腺苷积累的机制。
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3
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Cyclic 3',5'-nucleotide phosphodiesterase in rat skin. II. Biochemical characterization.大鼠皮肤中的环3',5'-核苷酸磷酸二酯酶。II. 生化特性
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引用本文的文献

1
Increased level of cAMP in the rat intestinal mucosa caused by sodium lauryl sulphate.
Naunyn Schmiedebergs Arch Pharmacol. 1977 Jul;298(3):263-6. doi: 10.1007/BF00500898.

本文引用的文献

1
Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues.腺苷酸环化酶。IV. 神经激素对脑及其他组织提取物中3',5'-磷酸腺苷形成的影响。
J Biol Chem. 1962 Apr;237:1239-43.
2
Adenyl cylase. I. Distribution, preparation, and properties.腺苷酸环化酶。I. 分布、制备及性质。
J Biol Chem. 1962 Apr;237:1220-7.
3
Formation constants for the complexes of adenosine di- or tri-phosphate with magnesium or calcium ions.腺苷二磷酸或三磷酸与镁离子或钙离子形成的配合物的形成常数。
Biochem J. 1959 Feb;71(2):388-95. doi: 10.1042/bj0710388.
4
Some speculations on the chemical nature of postjunctional membrane receptors.关于接头后膜受体化学性质的一些推测。
Fed Proc. 1967 Nov-Dec;26(6):1647-54.
5
Relationship of calcium and phosphates to bioelectric phenomena in the excitatory membrane.
Perspect Biol Med. 1965 Autumn;9(1):1-12. doi: 10.1353/pbm.1965.0025.
6
The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by NaF.大鼠脑组织匀浆中腺苷酸环化酶与其他利用ATP的酶及磷酸二酯酶活性的关系；氟化钠刺激环磷酸腺苷积累的机制。
Br J Pharmacol. 1973 Jul;48(3):505-15. doi: 10.1111/j.1476-5381.1973.tb08357.x.
7
Cyclic adenosine 3',5'-monophosphate formation in brain slices: stimulation by batrachotoxin, ouabain, veratridine, and potassium ions.
Mol Pharmacol. 1970 Mar;6(2):184-8.
8
Adenyl cyclase and hormone action. I. Effects of adrenocorticotropic hormone, glucagon, and epinephrine on the plasma membrane of rat fat cells.腺苷酸环化酶与激素作用。一、促肾上腺皮质激素、胰高血糖素和肾上腺素对大鼠脂肪细胞质膜的影响。
Proc Natl Acad Sci U S A. 1969 Jun;63(2):350-6. doi: 10.1073/pnas.63.2.350.
9
Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride.脂肪细胞中的腺苷酸环化酶。1. 性质以及促肾上腺皮质激素和氟化物的作用
J Biol Chem. 1969 Jul 10;244(13):3468-76.
10
The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.化学试剂对兔小脑切片中3',5'-磷酸腺苷积累的影响。
Mol Pharmacol. 1968 Jul;4(4):367-78.

大鼠脑组织匀浆中腺苷酸环化酶与其他利用ATP的酶及磷酸二酯酶活性的关系；肾上腺素、哇巴因和Mn++刺激环磷酸腺苷积累的机制。

The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by adrenaline, ouabain and Mn++.

作者信息

Katz S, Tenenhouse A

出版信息

Br J Pharmacol. 1973 Jul;48(3):516-26. doi: 10.1111/j.1476-5381.1973.tb08358.x.

DOI:10.1111/j.1476-5381.1973.tb08358.x
PMID:4148740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776116/
Abstract
  1. The mechanism of stimulation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) accumulation by adrenaline and ouabain and the effect of Mn(++) substitution for Mg(++) as the metal ion requirement of this system was studied in cell-free preparations of adenyl cyclase from rat brain.2. In the rat cerebral cortex preparation, substitution of Mn(++) for Mg(++) significantly increased cyclic AMP accumulation while significantly inhibiting adenosine triphosphate (ATP) and adenosine diphosphate (ADP) hydrolysis and adenosine 5'-monophosphate (AMP) accumulation. In the synaptic membrane preparation, in the absence of NaF, the highest amount of ATP hydrolysis was obtained in tissue prepared with Mn(++) and incubated with Mg(++); under these conditions cyclic AMP accumulation was equal to that produced under any other condition and significantly higher than that observed in the presence of Mg(++) prepared and Mg(++) incubated tissue.3. Preparation and/or incubation of tissue with Mn(++) significantly reduced phosphodiesterase (PDE) activity compared to that observed in Mg(++) prepared tissue.4. Adrenaline and ouabain both significantly increased cyclic AMP accumulation in the rat cerebral cortex preparation but did not inhibit ATP or ADP hydrolysis. In the synaptic membrane preparation, in the presence of 0.01 mM Ca(++), adrenaline but not ouabain significantly increased cyclic AMP accumulation. Phenoxybenzamine (0.1 mM) and pronethalol (0.1 mM) significantly inhibited adrenaline-induced cyclic AMP accumulation in both these preparations.5. Ouabain and adrenaline both failed to stimulate cyclic AMP accumulation in the presence of Mn(++) prepared and/or incubated tissue.6. Ouabain and adrenaline had no effect on PDE activity in either of these preparations.7. It was concluded that Mn(++) increased cyclic AMP accumulation in part by indirect inhibition of ATP and ADP hydrolysis which provides inhibitors of cyclic AMP destruction, by direct stimulation of adenyl cyclase and by inhibition of cyclic AMP destruction in a way unrelated to nucleotide inhibition of PDE. Adrenaline and ouabain appeared tp stimulate cyclic AMP accumulation in a more direct manner.
摘要

  1. 本研究在大鼠脑腺苷酸环化酶的无细胞制剂中，探讨了肾上腺素和哇巴因刺激环磷酸腺苷（cAMP）积累的机制，以及用Mn(++)替代Mg(++)作为该系统金属离子需求的影响。

  2. 在大鼠大脑皮层制剂中，用Mn(++)替代Mg(++)显著增加了cAMP积累，同时显著抑制了三磷酸腺苷（ATP）和二磷酸腺苷（ADP）水解以及一磷酸腺苷（AMP）积累。在突触膜制剂中，在无氟化钠的情况下，用Mn(++)制备并与Mg(++)孵育的组织中ATP水解量最高；在这些条件下，cAMP积累与在任何其他条件下产生的积累量相等，且显著高于用Mg(++)制备并与Mg(++)孵育的组织中观察到的积累量。

  3. 与用Mg(++)制备的组织相比，用Mn(++)制备和/或孵育组织显著降低了磷酸二酯酶（PDE）活性。

  4. 肾上腺素和哇巴因均显著增加了大鼠大脑皮层制剂中的cAMP积累，但未抑制ATP或ADP水解。在突触膜制剂中，在存在0.01 mM Ca(++)的情况下，肾上腺素而非哇巴因显著增加了cAMP积累。苯氧苄胺（0.1 mM）和普萘洛尔（0.1 mM）在这两种制剂中均显著抑制了肾上腺素诱导的cAMP积累。

  5. 在用Mn(++)制备和/或孵育的组织存在的情况下，哇巴因和肾上腺素均未能刺激cAMP积累。

  6. 哇巴因和肾上腺素对这两种制剂中的PDE活性均无影响。

  7. 得出的结论是，Mn(++)部分通过间接抑制ATP和ADP水解（从而提供cAMP破坏的抑制剂）、直接刺激腺苷酸环化酶以及以与核苷酸对PDE的抑制无关的方式抑制cAMP破坏来增加cAMP积累。肾上腺素和哇巴因似乎以更直接的方式刺激cAMP积累。