脒基取代的芳香杂环作为类胰蛋白酶特异性口袋的探针。 - Suppr

Suppr

超能文献

Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases.

作者信息

Geratz J D, Stevens F M, Polakoski K L, Parrish R F, Tidwell R R

出版信息

Arch Biochem Biophys. 1979 Oct 15;197(2):551-9. doi: 10.1016/0003-9861(79)90279-0.

DOI:10.1016/0003-9861(79)90279-0

PMID:41488

Abstract

摘要

相似文献

Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases.脒基取代的芳香杂环作为类胰蛋白酶特异性口袋的探针。

Arch Biochem Biophys. 1979 Oct 15;197(2):551-9. doi: 10.1016/0003-9861(79)90279-0.

Tetra-p-amidinophenoxy-propane as a probe of the specificity site of serine proteases.四对脒基苯氧基丙烷作为丝氨酸蛋白酶特异性位点的探针。

FEBS Lett. 1982 May 3;141(1):33-6. doi: 10.1016/0014-5793(82)80009-4.

Inhibition of trypsin, plasmin, thrombin and kallikrein by various esters of guanidino- and amidino-acids.

Biol Pharm Bull. 1994 Mar;17(3):446-8. doi: 10.1248/bpb.17.446.

A comprehensive study on the mechanism of inhibition of serine proteases by benzamidines based on quantitative structure-activity relationship studies.基于定量构效关系研究的苯甲脒对丝氨酸蛋白酶抑制机制的综合研究。

Arzneimittelforschung. 1987 Jan;37(1):47-50.

[Synthetic inhibitors of serine proteinases. Part 21: Studies on the structure-activity relationships in bisamidines (author's transl)].[丝氨酸蛋白酶的合成抑制剂。第21部分：双脒类化合物构效关系的研究（作者译）]

Pharmazie. 1979 Dec;34(12):837-9.

[Synthetic inhibitors of serine proteinases. 5. The inhibition of trypsin, plasmin and thrombin caused by aliphatic amidino compounds having ether structure as well as esters of the 3- and 4-amidinophenoxyfacetic acid].[丝氨酸蛋白酶的合成抑制剂。5. 具有醚结构的脂肪族脒基化合物以及3-和4-脒基苯氧基乙酸酯对胰蛋白酶、纤溶酶和凝血酶的抑制作用]

Pharmazie. 1975 Jun;30(6):386-9.

New aromatic diamidines with central alpha-oxyalkane or alpha, omega-dioxyalkane chains. Structure-activity relationships for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation process.

J Med Chem. 1975 May;18(5):477-81. doi: 10.1021/jm00239a007.

Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis.

J Med Chem. 1973 Oct;16(10):1102-6. doi: 10.1021/jm00268a008.

Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.芳香脒类：其阻断呼吸道合胞病毒诱导的细胞融合以及抑制纤溶酶、尿激酶、凝血酶和胰蛋白酶能力的比较。

J Med Chem. 1983 Feb;26(2):294-8. doi: 10.1021/jm00356a036.

[Synthetic inhibitors of serine proteinases. 2. Inhibitory effect of amidino benzoic acid homologues and of their esters in comparison with trypsin, plasmin and thrombin].

Pharmazie. 1974 May;29(5):333-6.

引用本文的文献

Facile one pot synthesis of 2-substituted benzimidazole derivatives under mild conditions by using engineered MgO@DFNS as heterogeneous catalyst.以工程化的MgO@DFNS作为多相催化剂，在温和条件下简便地一锅合成2-取代苯并咪唑衍生物。

RSC Adv. 2023 Nov 1;13(46):32110-32125. doi: 10.1039/d3ra05761e. eCollection 2023 Oct 31.

Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.芳香二脒肟前药的抗肺孢子菌活性。

Antimicrob Agents Chemother. 1998 Mar;42(3):666-74. doi: 10.1128/AAC.42.3.666.

The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.人α-凝血酶与非肽基活性位点导向抑制剂LY178550复合的晶体结构。

Protein Sci. 1997 Jul;6(7):1412-7. doi: 10.1002/pro.5560060705.

Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines.单脒和双脒对呼吸道合胞病毒与宿主细胞相互作用的抑制作用。

Antimicrob Agents Chemother. 1981 Apr;19(4):649-56. doi: 10.1128/AAC.19.4.649.

Effect of synthetic protease inhibitors of the amidine type on cell injury by Rickettsia rickettsii.脒类合成蛋白酶抑制剂对立氏立克次氏体所致细胞损伤的作用。

Antimicrob Agents Chemother. 1984 May;25(5):582-5. doi: 10.1128/AAC.25.5.582.

In vitro inhibition of human sarcoma cells' invasive ability by bis(5-amidino-2-benzimidazolyl)methane--a novel esteroprotease inhibitor.双（5-脒基-2-苯并咪唑基）甲烷——一种新型酯蛋白酶抑制剂对人肉瘤细胞侵袭能力的体外抑制作用

Am J Pathol. 1986 Apr;123(1):46-56.

Amelioration of immune complex-mediated glomerulonephritis by synthetic protease inhibitors.合成蛋白酶抑制剂对免疫复合物介导的肾小球肾炎的改善作用

Am J Pathol. 1987 Jun;127(3):499-506.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验