阿托品样药物与大鼠脑中含多巴胺神经元的相互作用。
Interaction of atropine-like drugs with dopamine-containing neurones in rat brain.
作者信息
Bowers M B, Roth R H
出版信息
Br J Pharmacol. 1972 Feb;44(2):301-6. doi: 10.1111/j.1476-5381.1972.tb07267.x.
Abstract
- A variety of atropine-like drugs effective in the treatment of drug-induced extrapyramidal syndromes have been investigated with regard to their interaction with dopamine-containing neurones in rat brain.2. Under some conditions benztropine, trihexyphenidyl, atropine and ethopropazine significantly antagonized the chlorpromazine-induced increase in subcortical concentrations of homovanillic acid.3. Most of the atropine-like drugs investigated also decreased the turnover of dopamine in the subcortex as measured by following the disappearance of dopamine after administration of alpha-methyl-p-tyrosine.4. These findings are suggestive that an imbalance between a dopaminergic and cholinergic system might be closely linked to the pathogenesis of extra-pyramidal movement disorders.
摘要
已对多种有效治疗药物性锥体外系综合征的阿托品样药物，就其与大鼠脑中含多巴胺神经元的相互作用进行了研究。
在某些条件下，苯海索、三己芬迪、阿托品和乙丙嗪显著拮抗氯丙嗪引起的皮层下高香草酸浓度升高。
所研究的大多数阿托品样药物还降低了皮层下多巴胺的周转率，这是通过给予α-甲基对酪氨酸后观察多巴胺的消失来测定的。
这些发现提示，多巴胺能和胆碱能系统之间的失衡可能与锥体外系运动障碍的发病机制密切相关。
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