Lambert R, André C, Moulinier B, Bugnon B
Digestion. 1978;17(2):159-67. doi: 10.1159/000198106.
During 8 years experience, 90 cases of diffuse varioliform gastritis were observed (0.3% of examinations). Symptoms suggest either the presence of a gastroduodenal ulcer or of a digestive carcinoma when weight loss is prevalent. The disease proceeds by subacute evolutive bouts with remissions and further relapses. At endoscopy, lesions associate large folds in the fundus and erosive mucosal bulgings disseminated in the fundus and antrum. Histological alterations correspond to a superficial hyperplasic gastritis. Cellular infiltration of the lamina propria includes increased immunocytes population with an abnormal distribution of immunoglobulin classes. An increased percentage of IgE cells characterizes the disease as compared to inflammation in atrophic gastritis. Therapy is based upon agent inhibiting mastocytes degranulation and histamine antagonists. Diffuse varioliform gastritis must be separated from antral varioliform gastritis, a lesion with a higher frequency but no symptomatic individuality.
在8年的临床经验中，共观察到90例弥漫性痘疮样胃炎（占检查病例的0.3%）。当体重减轻较为普遍时，症状提示可能存在胃十二指肠溃疡或消化道癌。该病呈亚急性进行性发作，有缓解期和复发期。内镜检查时，病变表现为胃底大皱襞以及散在于胃底和胃窦的糜烂性黏膜隆起。组织学改变符合浅表性增生性胃炎。固有层细胞浸润包括免疫细胞数量增加以及免疫球蛋白类别的异常分布。与萎缩性胃炎炎症相比，IgE细胞百分比增加是该病的特征。治疗基于抑制肥大细胞脱颗粒的药物和组胺拮抗剂。弥漫性痘疮样胃炎必须与胃窦痘疮样胃炎相鉴别，后者发病率较高，但无明显症状特征。
