糜烂性胃炎与胃酸分泌区域及肠化生的关系，以及哌仑西平的治疗效果。
Relationship of erosive gastritis to the acid secreting area and intestinal metaplasia, and the healing effect of pirenzepine.
作者信息
Tatsuta M, Iishi H, Okuda S
出版信息
Gut. 1987 May;28(5):561-5. doi: 10.1136/gut.28.5.561.
Abstract
The extent of acid secreting areas and the distribution of intestinal metaplasia in patients with erosive gastritis, and the healing effects of pirenzepine were examined. Studies were done with the endoscopic Congo red-methylene blue test developed in our hospital. Compared with control patients with no gastroduodenal disease, erosive gastritis was associated significantly more frequently with large acid secreting areas, but little or no intestinal metaplasia was detected in the stomach. A double blind trial was carried out, using 100 mg pirenzepine tablets or placebo for three months in 43 patients with erosive gastritis. Endoscopically, complete healing was significantly more frequent in the pirenzepine treated groups three months after the start of the treatment, as compared with the placebo treated group (p less than 0.05).
摘要
研究了糜烂性胃炎患者胃酸分泌区域的范围和肠化生的分布情况，以及哌仑西平的治疗效果。采用我院研发的内镜下刚果红-亚甲蓝试验进行研究。与无胃十二指肠疾病的对照患者相比，糜烂性胃炎患者胃酸分泌区域大的情况更为常见，但胃内肠化生很少或未检测到。对43例糜烂性胃炎患者进行了双盲试验，给予100mg哌仑西平片或安慰剂，为期3个月。在内镜检查中，治疗开始3个月后，哌仑西平治疗组的完全愈合率明显高于安慰剂治疗组（p<0.05）。
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本文引用的文献
1
Occurrence of gastric mucosal erosions in association with other upper gastrointestinal diseases, especially peptic ulcer disease, as revealed by elective gastroscopy.
Scand J Gastroenterol. 1982 Nov;17(8):977-84.
2
Endoscopic diagnosis of early gastric cancer by the endoscopic Congo red-methylene blue test.
Cancer. 1982 Dec 15;50(12):2956-60. doi: 10.1002/1097-0142(19821215)50:12<2956::aid-cncr2820501242>3.0.co;2-a.
3
Age-related changes in the acid-secreting area in patients with duodenal ulcer.
Endoscopy. 1983 Jul;15(4):243-5. doi: 10.1055/s-2007-1021523.
4
Randomised placebo-controlled double-blind trial of two dosages of sodium cromoglycate in treatment of varioliform gastritis: comparison with cimetidine.
Gut. 1982 Apr;23(4):348-52. doi: 10.1136/gut.23.4.348.
5
The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens.
J Clin Pathol. 1972 Jan;25(1):1-11. doi: 10.1136/jcp.25.1.1.
6
Erosive prepyloric changes in persons with and without dyspepsia.
Scand J Gastroenterol. 1985 Mar;20(2):222-8. doi: 10.3109/00365528509089661.
7
Prepyloric erosions and related changes.
Scand J Gastroenterol. 1985 Sep;20(7):779-82. doi: 10.3109/00365528509088822.
8
Effect of cimetidine in patients with non-ulcer dyspepsia and erosive prepyloric changes.
Scand J Gastroenterol. 1985 Jun;20(5):629-35. doi: 10.3109/00365528509089708.
9
Chronic erosive (verrucous) gastritis. A study of 108 patients.
Endoscopy. 1977 May;9(2):74-8. doi: 10.1055/s-0028-1098492.
10
[Anti-ulcer agent pirenzepine (LS 519)--a tricyclic compound with particular physico-chemical properties (author's transl)].
Arzneimittelforschung. 1977 Feb;27(2):356-9.
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