人体中选择性β-肾上腺素能受体阻滞的评估。
Assessment of selective beta-adrenoceptor blockade in man.
作者信息
Briant R H, Dollery C T, Fenyvesi T, George C F
出版信息
Br J Pharmacol. 1973 Sep;49(1):106-14. doi: 10.1111/j.1476-5381.1973.tb08272.x.
Abstract
- Selective antagonism of the cardiac beta(1)-adrenoceptors has been studied in normal human volunteers.2. Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective beta-adrenoceptor blockade in 2 of 3 subjects studied.3. Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre.4. A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.
摘要
已在正常人类志愿者中研究了心脏β₁肾上腺素能受体的选择性拮抗作用。
心得宁和UK 6558对静脉注射异丙肾上腺素引起的变时性和变力性反应的拮抗作用，比对静脉注射或动脉内注射异丙肾上腺素引起的血管舒张反应的拮抗作用更强。第三种药物M&B 17,803A在3名研究对象中的2名中产生了非选择性β肾上腺素能受体阻断作用。
心得宁、UK 6558和M&B 17,803A使瓦尔萨尔瓦动作的反应减弱。
给予UK 6558的4名血压正常的受试者中有3名出现了血压大幅下降。
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