Barnes B W, Birley A J
Heredity (Edinb). 1978 Feb;40(1):51-7. doi: 10.1038/hdy.1978.6.
Chromosome substitution lines derived from two inbred strains of Drosophila melanogaster homozygous for the AdhS allele of alcohol dehydrogenase but differing significantly in ADH activity have been analysed. Variation in activity can be attributed to all three major chromosomes. The effect of the second chromosome, where the ADH structural gene is located, can be modified significantly by the genotype of both the first and the third chromosomes. The most substantial single effect results from homozygous differences between the third chromosomes. In contrast, differences between the X chromosomes are revealed only when the second or second and third chromosomes are heterozygous.
对从两个纯合子果蝇品系衍生而来的染色体替代系进行了分析，这两个品系对于乙醇脱氢酶的AdhS等位基因是纯合的，但在乙醇脱氢酶活性上有显著差异。活性的变化可归因于所有三条主要染色体。乙醇脱氢酶结构基因所在的第二条染色体的效应，会受到第一条和第三条染色体基因型的显著影响。最显著的单一效应来自第三条染色体的纯合差异。相比之下，只有当第二条或第二条和第三条染色体为杂合子时，X染色体之间的差异才会显现出来。
