• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇中乙醇脱氢酶（Adh）基因座产物之间的生化差异。

Biochemical differences between products of the Adh locus in Drosophila.

作者信息

McDonald J F, Anderson S M, Santos M

出版信息

Genetics. 1980 Aug;95(4):1013-22. doi: 10.1093/genetics/95.4.1013.

DOI:10.1093/genetics/95.4.1013
PMID:6781982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1214263/
Abstract

An analysis of the molecular properties of the major alcohol dehydrogenase (E.C.1.1.1.1.) allozyme variants found segregating in natural populations of D. melanogaster is presented. Our results indicate: (1) ADH-S enzyme has generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype. The possible adaptive significance of these findings is discussed.

摘要

本文对在黑腹果蝇自然种群中发现的主要乙醇脱氢酶（E.C.1.1.1.1.）同工酶变体的分子特性进行了分析。我们的结果表明：（1）ADH-S酶的米氏常数通常比ADH-F酶的低；（2）ADH-S和ADH-F酶对辅因子和底物均表现出相反的相互作用；（3）较高水平的ADH与Adh-fast基因型相关。本文还讨论了这些发现可能具有的适应性意义。

相似文献

1
Biochemical differences between products of the Adh locus in Drosophila.果蝇中乙醇脱氢酶（Adh）基因座产物之间的生化差异。
Genetics. 1980 Aug;95(4):1013-22. doi: 10.1093/genetics/95.4.1013.
2
An electrophoretically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. III. Biochemical properties and comparison with common enzyme forms.果蝇中一种电泳隐性醇脱氢酶变体。III. 生化特性及与常见酶形式的比较。
Aust J Biol Sci. 1981;34(5-6):625-37. doi: 10.1071/bi9810625.
3
Biochemical and molecular analysis of naturally occurring Adh variants in Drosophila melanogaster.黑腹果蝇中天然存在的乙醇脱氢酶变体的生化与分子分析
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4798-802. doi: 10.1073/pnas.80.15.4798.
4
An electrophoretically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. I. Activity ratios, thermostability, genetic localization and comparison with two other thermostable variants.黑腹果蝇中一种电泳隐性醇脱氢酶变体。I. 活性比率、热稳定性、基因定位以及与其他两种热稳定变体的比较。
Aust J Biol Sci. 1980 Aug;33(4):479-89. doi: 10.1071/bi9800479.
5
Variation in amount of enzyme protein in natural populations.自然种群中酶蛋白数量的变异。
Biochem Genet. 1978 Apr;16(3-4):159-70. doi: 10.1007/BF00484075.
6
Genetical variation for enzyme activity in a population of Drosophila melanogaster. VI. Molecular variation in the control of alcohol dehydrogenase (ADH) activity.黑腹果蝇群体中酶活性的遗传变异。VI. 乙醇脱氢酶（ADH）活性控制中的分子变异。
Heredity (Edinb). 1981 Oct;47(2):185-96. doi: 10.1038/hdy.1981.75.
7
Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster.自然种群中酶活性变异的遗传和生化基础。I. 黑腹果蝇中的乙醇脱氢酶
Genetics. 1978 Jun;89(2):371-88. doi: 10.1093/genetics/89.2.371.
8
Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.黑腹果蝇乙醇脱氢酶基因座上电泳相同的等位基因之间的变异。
Biochem Genet. 1975 Oct;13(9-10):721-31. doi: 10.1007/BF00484929.
9
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.黑腹果蝇乙醇脱氢酶基因座的核苷酸多态性
Nature. 1983;304(5925):412-7. doi: 10.1038/304412a0.
10
Alcohol dehydrogenase of Drosophila melanogaster: metabolic differences mediated through cryptic allozymes.黑腹果蝇的乙醇脱氢酶：由隐性等位酶介导的代谢差异
Heredity (Edinb). 1986 Aug;57 ( Pt 1):23-9. doi: 10.1038/hdy.1986.82.

引用本文的文献

1
Different genetic basis for alcohol dehydrogenase activity and plasticity in a novel alcohol environment for Drosophila melanogaster.在一个新的酒精环境中，黑腹果蝇的酒精脱氢酶活性和可塑性具有不同的遗传基础。
Heredity (Edinb). 2020 Sep;125(3):101-109. doi: 10.1038/s41437-020-0323-y. Epub 2020 Jun 1.
2
ALCOHOL TOLERANCE, ADH ACTIVITY, AND ECOLOGICAL NICHE OF DROSOPHILA SPECIES.果蝇物种的酒精耐受性、乙醇脱氢酶活性与生态位
Evolution. 1994 Jun;48(3):746-757. doi: 10.1111/j.1558-5646.1994.tb01358.x.
3
Genetics and genomics of alcohol sensitivity.酒精敏感性的遗传学和基因组学。
Mol Genet Genomics. 2014 Jun;289(3):253-69. doi: 10.1007/s00438-013-0808-y. Epub 2014 Jan 7.
4
Estimating single gene effects on quantitative traits : 2. Statistical properties of five experimental methods.估计数量性状的单个基因效应：五重实验方法的统计性质。
Theor Appl Genet. 1985 Mar;69(5-6):631-6. doi: 10.1007/BF00251115.
5
Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster.黑腹果蝇对酒精敏感性选择的表型和转录反应。
Genome Biol. 2007;8(10):R231. doi: 10.1186/gb-2007-8-10-r231.
6
Genetic Localization and Biochemical Characterization of a TRANS-Acting Regulatory Effect in Drosophila.果蝇中转录调节效应的遗传定位和生化特性分析。
Genetics. 1983 Sep;105(1):55-69. doi: 10.1093/genetics/105.1.55.
7
Evolutionary genetics of the Drosophila alcohol dehydrogenase gene-enzyme system.果蝇乙醇脱氢酶基因-酶系统的进化遗传学
Genetica. 1993;92(1):1-22. doi: 10.1007/BF00057503.
8
Micro-evolution in a wine cellar population: an historical perspective.酒窖菌群中的微进化：历史视角
Genetica. 1993;90(2-3):201-15. doi: 10.1007/BF01435040.
9
Genetic variation in the expression of ADH in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（ADH）表达的遗传变异。
Genetics. 1982 Jul-Aug;101(3-4):431-46. doi: 10.1093/genetics/101.3-4.431.
10
Selection at the alcohol dehydrogenase locus of Drosophila melanogaster: effects of ethanol and temperature.黑腹果蝇乙醇脱氢酶基因座的选择：乙醇和温度的影响。
Biochem Genet. 1982 Aug;20(7-8):681-8. doi: 10.1007/BF00483965.

本文引用的文献

1
Quantitative genetic variation of enzyme activities in natural populations of Drosophila melanogaster.自然种群中黑腹果蝇酶活性的数量遗传变异。
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1073-7. doi: 10.1073/pnas.77.2.1073.
2
Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli.大肠杆菌中二磷酸吡啶核苷酸的生物合成途径。
J Biol Chem. 1961 May;236:1494-7.
3
Graphical determination of the dissociation constants for two-substrate enzyme systems.双底物酶系统解离常数的图形测定法。
Biochim Biophys Acta. 1957 Sep;25(3):575-8. doi: 10.1016/0006-3002(57)90529-2.
4
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
5
Differences in the number of molecules produced by two allelic electrophoretic enzyme variants in D. melanogaster.黑腹果蝇中两个等位基因电泳酶变体所产生的分子数量差异。
Experientia. 1972 Aug 15;28(8):975-6. doi: 10.1007/BF01924982.
6
Variation in ADH activity in class I and class II strains of Drosophila.
J Hered. 1974 May-Jun;65(3):141-8. doi: 10.1093/oxfordjournals.jhered.a108485.
7
The relative quantities and catalytic activities of enzymes produced by alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.果蝇酒精脱氢酶基因座上等位基因所产生的酶的相对数量和催化活性。
Biochem Genet. 1974 Feb;11(2):155-65. doi: 10.1007/BF00485771.
8
A computer program for fitting and statistically analyzing initial rate data applied to bovine hexokinase type III isozyme.一种用于拟合和统计分析应用于牛Ⅲ型己糖激酶同工酶的初始速率数据的计算机程序。
Arch Biochem Biophys. 1975 Oct;170(2):587-600. doi: 10.1016/0003-9861(75)90154-x.
9
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
10
Genetical variation for enzyme activity in a population of Drosophila melanogaster. IV. Analysis of alcohol dehydrogenase activity in chromosome substitution lines.黑腹果蝇群体中酶活性的遗传变异。IV. 染色体代换系中乙醇脱氢酶活性的分析。
Heredity (Edinb). 1978 Feb;40(1):51-7. doi: 10.1038/hdy.1978.6.