果蝇中乙醇脱氢酶（Adh）基因座产物之间的生化差异。
Biochemical differences between products of the Adh locus in Drosophila.
作者信息
McDonald J F, Anderson S M, Santos M
出版信息
Genetics. 1980 Aug;95(4):1013-22. doi: 10.1093/genetics/95.4.1013.
Abstract
An analysis of the molecular properties of the major alcohol dehydrogenase (E.C.1.1.1.1.) allozyme variants found segregating in natural populations of D. melanogaster is presented. Our results indicate: (1) ADH-S enzyme has generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype. The possible adaptive significance of these findings is discussed.
摘要
本文对在黑腹果蝇自然种群中发现的主要乙醇脱氢酶（E.C.1.1.1.1.）同工酶变体的分子特性进行了分析。我们的结果表明：（1）ADH-S酶的米氏常数通常比ADH-F酶的低；（2）ADH-S和ADH-F酶对辅因子和底物均表现出相反的相互作用；（3）较高水平的ADH与Adh-fast基因型相关。本文还讨论了这些发现可能具有的适应性意义。
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