绵羊支气管和猫气管中的组胺H2受体：布立马胺的作用
Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide.
作者信息
Eyre P
出版信息
Br J Pharmacol. 1973 Jun;48(2):321-3. doi: 10.1111/j.1476-5381.1973.tb06920.x.
Abstract
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence of H(2)-receptors. Mepyramine or burimamide alone produced partial antagonism of histamine-induced relaxation of the cat trachea. Both inhibitors added simultaneously effectively abolished the histamine response, suggesting that both H(1)- and H(2)-receptors are active in relaxing the cat trachea.
摘要
组胺诱导的绵羊支气管舒张作用被布立马胺拮抗，但不被美吡拉敏拮抗，这表明存在H(2)受体。单独使用美吡拉敏或布立马胺可部分拮抗组胺诱导的猫气管舒张。同时加入这两种抑制剂可有效消除组胺反应，提示H(1)和H(2)受体在猫气管舒张中均起作用。
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