标准化异丙肾上腺素敏感性试验——现有方法的比较
Standardised isoprenaline sensitivity tests--a comparison of existent methods.
作者信息
Arnold J M, McDevitt D G
出版信息
Br J Clin Pharmacol. 1983 Feb;15(2):167-72. doi: 10.1111/j.1365-2125.1983.tb01482.x.
Abstract
1 Six healthy subjects (four male, two female, aged 19-24 years) received intravenous boluses of isoprenaline sulphate by two standardised methods of injection (Cleaveland et al., 1972; George et al., 1972). Heart rate changes were analysed by three different methods. 2 The I25 (dose of isoprenaline required to increase the heart rate by 25 beats/min) was not significantly altered by either the method of injection or the method of heart rate measurement. 3 The slope of the heart rate dose response curve was significantly steeper when isoprenaline was injected in a fixed 2 ml volume through a three-way tap, and when the heart rate was measured from the shortest three R-R intervals. 4 However the differences in method of injection and heart rate measurement between the two techniques do not appear to produce major alterations in the results obtained, particularly the I25.
摘要
- 六名健康受试者（四名男性，两名女性，年龄19 - 24岁）通过两种标准化注射方法（克利夫兰等人，1972年；乔治等人，1972年）接受硫酸异丙肾上腺素静脉推注。采用三种不同方法分析心率变化。2. 注射方法或心率测量方法均未使心率增加25次/分钟所需的异丙肾上腺素剂量（I25）发生显著改变。3. 当通过三通阀以固定的2毫升体积注射异丙肾上腺素，且从最短的三个R - R间期测量心率时，心率剂量反应曲线的斜率明显更陡。4. 然而，两种技术在注射方法和心率测量方面的差异似乎并未对所得结果产生重大改变，尤其是I25。
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