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1
Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro.组胺H1和H2受体拮抗剂与豚鼠离体心房及小鼠肿瘤性肥大细胞体外组胺摄取和代谢的相互作用。
Br J Pharmacol. 1975 Apr;53(4):569-74. doi: 10.1111/j.1476-5381.1975.tb07396.x.
2
The influence of burimamide on 14C-histamine uptake and metabolism by guinea pig atrium and mouse neoplastic mast cells, in vitro.
Agents Actions. 1973 Oct;3(3):187-9. doi: 10.1007/BF01965745.
3
The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro.在体外实验中，甲硫咪胺对豚鼠心房和小鼠肿瘤性肥大细胞中组胺摄取及代谢的抑制作用。
Br J Pharmacol. 1973 Oct;49(2):361-3. doi: 10.1111/j.1476-5381.1973.tb08384.x.
4
The pharmacology of burimamide and metiamide, two histamine H2-receptor antagonists.两种组胺H2受体拮抗剂——布立马胺和甲硫米特的药理学
Fed Proc. 1976 Jun;35(8):1931-4.
5
Proceedings: Definition of the antagonistic action of burimamide and metiamide on the positive inotropic effect of histamine in isolated heart preparations.论文：布立马胺和甲硫咪胺对离体心脏制剂中组胺正性肌力作用的拮抗作用定义。
Br J Pharmacol. 1974 Nov;52(3):457P-458P.
6
Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.在离体犬心房中，丁咪胺和甲硫咪胺对组胺引起的正性变时性和变力性反应无阻断作用。
Jpn J Pharmacol. 1977 Apr;27(2):267-73. doi: 10.1254/jjp.27.267.
7
Effects of the H1-antagonist promethazine and the H2-antagonist burimamide on chronotropic, inotropic and coronary vascular responses to histamine in isolated perfused guinea-pig hearts.H1拮抗剂异丙嗪和H2拮抗剂布立马胺对离体灌注豚鼠心脏中组胺引起的变时性、变力性及冠状血管反应的影响。
Agents Actions. 1976 Nov;6(6):683-8. doi: 10.1007/BF02026088.
8
Action of H1 and H2 inhibitors on the response of histamine sensitive adenyly cyclase from guinea-pig mucosa.H1和H2抑制剂对豚鼠黏膜组胺敏感性腺苷酸环化酶反应的作用。
Eur J Clin Invest. 1976 Jan 30;6(1):113-20. doi: 10.1111/j.1365-2362.1976.tb00500.x.
9
Effect of the H2-receptor antagonists (burimamide and metiamide) on gastric secretion stimulated by histamine and its methyl derivatives.H2受体拮抗剂（布立马胺和甲硫米特）对组胺及其甲基衍生物刺激的胃酸分泌的影响。
J Pharmacol Exp Ther. 1975 May;193(2):614-20.
10
Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-and H2-receptor agonists and antagonists.心脏组胺受体的药理学特性：对H1和H2受体激动剂及拮抗剂的敏感性
Eur J Pharmacol. 1975 Feb;30(2):328-35. doi: 10.1016/0014-2999(75)90117-x.

引用本文的文献

1
Proceedings of the British Pharmacological Society. 17th-19th December, 1979: University of London (Institute of Education).英国药理学会会议记录。1979年12月17日至19日：伦敦大学（教育学院）
Br J Pharmacol. 1980 Jun;69(2):265P-346P.
2
Indirect adrenergic effect of histamine in cat cerebral arteries.组胺对猫脑动脉的间接肾上腺素能效应。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):239-43. doi: 10.1007/BF00499153.
3
Uptake and metabolism of histamine in guinea-pig isolated atria and their relationship to the pharmacological responses.组胺在豚鼠离体心房中的摄取与代谢及其与药理反应的关系。
Naunyn Schmiedebergs Arch Pharmacol. 1980;315(2):155-61. doi: 10.1007/BF00499258.
4
Acceleration of rat brain beta-adrenoceptor subsensitivity following the coadministration of histamine receptor antagonists with imipramine.组胺受体拮抗剂与丙咪嗪联合给药后大鼠脑β-肾上腺素能受体亚敏感性的加速
Agents Actions. 1989 Nov;28(3-4):153-8. doi: 10.1007/BF01967394.
5
Effect of histamine H2-receptor and beta-receptor blockade on histamine-, orciprenaline- and prostaglandin-stimulated frequency of the isolated guinea-pig atrium.组胺H2受体和β受体阻断对组胺、奥西那林和前列腺素刺激的离体豚鼠心房频率的影响。
Agents Actions. 1975 Dec;5(5):444-7. doi: 10.1007/BF01972664.
6
Enzymic histamine metabolism in guinea-pig skin and its role in immediate hypersensitivity reactions.豚鼠皮肤中的组胺酶代谢及其在速发型超敏反应中的作用。
Clin Exp Immunol. 1976 Dec;26(3):583-9.
7
The effects of metiamide and H1 receptor blocking agents on anaphylactic response in guinea-pigs.甲硫米特和H1受体阻断剂对豚鼠过敏反应的影响。
Agents Actions. 1979 Dec;9(5-6):467-73. doi: 10.1007/BF01968112.
8
The effects of H2-receptor antagonists on anaphylaxis in the guinea-pig.H2受体拮抗剂对豚鼠过敏反应的影响。
Agents Actions. 1978 Dec;8(6):559-65. doi: 10.1007/BF01998882.
9
The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells.α-肾上腺素能受体对组胺释放的调节作用：来自小鼠肿瘤性肥大细胞的证据
Agents Actions. 1977 Mar;7(1):57-61. doi: 10.1007/BF01964881.
10
Studies on the 14C-histamine release induced by histamine in mouse neoplastic mast cells.
Agents Actions. 1975 Dec;5(5):424-6. doi: 10.1007/BF01972658.

本文引用的文献

1
Release of endogenous serotonin and histamine from murine mastocytoma cells by various exogenous amines.
Eur J Pharmacol. 1968 Nov;4(4):427-34. doi: 10.1016/0014-2999(68)90030-7.
2
Determination of histidine decarboxylase activity.组氨酸脱羧酶活性的测定
Methods Biochem Anal. 1968;16:273-91. doi: 10.1002/9780470110348.ch5.
3
Uptake, disposition and metabolism of histamine in isolated heart preparations.组胺在离体心脏制剂中的摄取、分布与代谢
Br J Pharmacol. 1973 Nov;49(3):457-65. doi: 10.1111/j.1476-5381.1973.tb17256.x.
4
Histamine methyltransferase: inhibition and potentiation by antihistamines.组胺甲基转移酶：抗组胺药对其的抑制与增强作用
Mol Pharmacol. 1972 May;8(3):300-10.
5
Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
6
Inhibition of histamine-N-methylation by some antihistamines.某些抗组胺药对组胺-N-甲基化的抑制作用。
Biochem Pharmacol. 1967 Aug;16(8):1627-31. doi: 10.1016/0006-2952(67)90141-4.
7
The mechanism of the potentiation of norepinephrine by antihistaminics.抗组胺药增强去甲肾上腺素作用的机制。
J Pharmacol Exp Ther. 1967 Jun;156(3):463-8.
8
Receptors mediating some actions of histamine.介导组胺某些作用的受体。
Br J Pharmacol Chemother. 1966 Aug;27(2):427-39. doi: 10.1111/j.1476-5381.1966.tb01674.x.
9
Cocaine and antihistaminic compounds: comparison of effects of some cardiovascular actions of norepinephrine, tyramine and bretylium.可卡因与抗组胺化合物：去甲肾上腺素、酪胺和溴苄铵某些心血管作用效果的比较
J Pharmacol Exp Ther. 1966 Jun;152(3):458-68.
10
The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.肾上腺素能药物和去甲肾上腺素对体外心脏过敏反应中组胺释放的影响。
J Physiol. 1966 Jun;184(4):924-41. doi: 10.1113/jphysiol.1966.sp007957.

组胺H1和H2受体拮抗剂与豚鼠离体心房及小鼠肿瘤性肥大细胞体外组胺摄取和代谢的相互作用。

Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro.

作者信息

Fantozzi R, Franconi F, Mannaioni P F, Masini E, Moroni F

出版信息

Br J Pharmacol. 1975 Apr;53(4):569-74. doi: 10.1111/j.1476-5381.1975.tb07396.x.

DOI:10.1111/j.1476-5381.1975.tb07396.x
PMID:238704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666314/
Abstract
  1. Burimamide, metiamide, chlorpheniramine, triprolidine and cocaine, were tested as inhibitors of histamine uptake and metabolism in the guinea-pig atrium and in mouse neoplastic mast cells. 2. Cocaine did not affect the uptake and metabolism of histamine, either in the atrium or in the mast cells. All the antihistamines tested blocked the uptake and metabolism of histamine in both preparations. The order of potency was burimamide greater than chlorpheniramine greater than triprolidine greater than metiamide in the atrium; and burimamide greater than metiamide greater than triprolidine greater than chlorpheniramine, in the mase cells. 3. Comparison of the present results with the antihistamine activity of these blocking agents suggests that no correlation exists between the receptor blocking activity and the ability of these substances to act as inhibitors of histamine uptake and metabolism.
摘要
  1. 对丁咪胺、甲硫咪胺、氯苯那敏、曲普利啶和可卡因进行了测试，以研究它们对豚鼠心房和小鼠肿瘤性肥大细胞中组胺摄取和代谢的抑制作用。2. 可卡因对心房或肥大细胞中组胺的摄取和代谢均无影响。所有测试的抗组胺药均能阻断两种制剂中组胺的摄取和代谢。在心房中，效力顺序为丁咪胺＞氯苯那敏＞曲普利啶＞甲硫咪胺；在肥大细胞中，效力顺序为丁咪胺＞甲硫咪胺＞曲普利啶＞氯苯那敏。3. 将目前的结果与这些阻断剂的抗组胺活性进行比较表明，受体阻断活性与这些物质作为组胺摄取和代谢抑制剂的能力之间不存在相关性。