T淋巴细胞的分化途径。两种分化细胞类型的证据。
The differentiation pathway of T lymphocytes. Evidence for two differentiated cell types.
作者信息
Matter A
出版信息
J Exp Med. 1974 Aug 1;140(2):566-77. doi: 10.1084/jem.140.2.566.
Abstract
Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells.
摘要
已经使用两种实验模型来研究T细胞分化。第一种是移植物抗宿主反应，通过将胸腺细胞或皮质激素抗性胸腺细胞注射到致死性照射的同种异体小鼠中诱导产生。第二种是同种异体宿主中的肿瘤移植排斥反应。在不同时间间隔进行的超微结构研究揭示了两种分化的T细胞类型。其中一种（“浅色”细胞）在铬释放试验中测定可能具有高细胞毒性，另一种（“深色”细胞）可能是“放大”细胞，有助于细胞毒性细胞的分化。
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