腹水肿瘤同种异体移植的排斥反应。II. 腹膜渗出液淋巴细胞在体外介导细胞性肿瘤破坏的途径。
Rejection of ascites tumor allografts. II. A pathway for cell-mediated tumor destruction in vitro by peritoneal exudate lymphoid cells.
作者信息
Berke G, Sullivan K A, Amos B
出版信息
J Exp Med. 1972 Dec 1;136(6):1594-604. doi: 10.1084/jem.136.6.1594.
Abstract
A pathway for cell-mediated tumor destruction in vitro by immune peritoneal exudate lymphoid cells has been proposed. The union of lymphocytes and tumor cells precedes the formation of an intermediate phase leading to lysis. The initial interaction is only partially temperature dependent. The cytolytic process per se is highly temperature dependent, being negligible at 25 degrees C but proceeding rapidly at 37 degrees C. (51)Cr release from tumor cells is demonstrable within 10 min at 37 degrees C and can be reversibly arrested by cooling. Once initiated, lysis is largely independent of additional interactions and continues at almost full rate for 30 min. The effector cells are not lysed and appear to be free to enter into further effector cycles.
摘要
有人提出了一种免疫腹膜渗出淋巴细胞在体外介导细胞杀伤肿瘤的途径。淋巴细胞与肿瘤细胞的结合先于导致细胞溶解的中间阶段的形成。最初的相互作用仅部分依赖温度。细胞溶解过程本身高度依赖温度，在25℃时可忽略不计，但在37℃时迅速进行。在37℃下，肿瘤细胞的（51）铬释放可在10分钟内得到证实，并且可通过冷却而可逆地停止。一旦启动，细胞溶解在很大程度上独立于额外的相互作用，并以几乎全速持续30分钟。效应细胞不会被溶解，并且似乎可以自由进入进一步的效应循环。
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