Mejer J, Mortensen K M, Hansen H H
Scand J Respir Dis. 1977 Dec;58(6):319-23.
The effect of local instillation of mepacrine hydrochloride (quinacrine hydrochloride U.S.P., Atabrine) was compared with triethylenethiophosphoramide (Thiotepa) applied locally and with pleurocentesis alone. Twentyfive patients with disseminated malignant disease were allocated at random to one of these three treatments. A finding of more than 500 ml effusion within 3 months of instituting treatment was regarded as a failure, and subsequently one of the other treatments was used at random. Sixty-four per cent of the patients treated with mepacrine responded, compared with 27% treated with triethylenethiophosphoramide, and 11% treated with pleurocentesis alone.
将盐酸米帕林（美国药典中的盐酸阿的平）局部滴注的效果与局部应用三乙烯硫代磷酰胺（噻替派）以及单纯胸腔穿刺的效果进行了比较。25例播散性恶性疾病患者被随机分配至这三种治疗方法中的一种。在开始治疗后3个月内积液超过500毫升的情况被视为治疗失败，随后随机采用其他治疗方法之一。接受米帕林治疗的患者中有64%有反应，相比之下，接受三乙烯硫代磷酰胺治疗的患者为27%，单纯接受胸腔穿刺治疗的患者为11%。
