Elleder M, Povýsil C, Rozkovcová J, Cihula J
Virchows Arch B Cell Pathol. 1977 Dec 30;26(2):139-45. doi: 10.1007/BF02889543.
A histochemical study of enzymatic activities was undertaken in five cases of histiocytosis X (two localized bone forms, two generalized forms, and one involving mainly the skin), each of which revealed characteristic structural features at the optical and ultrastructural levels. A confirmation was made of the original assumption of high acid alpha-D-mannosidase activity, i.e. activity described in human Langerhans intraepidermal cells (Elleder, 1975). In the control group of tumors, with the exception of urticaria pigmentosa, enzyme activity was either at trace level or altogether absent. Acid alpha-D-mannosidase activity therefore appears to be the first biochemical feature common to both histiocytosis X and the Langerhans cells. The significance of the finding for the present theory of the histogenesis of the above tumors is discussed.
对5例组织细胞增多症X（2例局限于骨骼型、2例全身型、1例主要累及皮肤型）进行了酶活性的组织化学研究，每例在光学和超微结构水平均显示出特征性结构特点。证实了最初关于高酸性α-D-甘露糖苷酶活性的假设，即人类表皮内朗格汉斯细胞中所述的活性（埃勒德，1975年）。在肿瘤对照组中，除色素性荨麻疹外，酶活性要么处于痕量水平，要么完全缺失。因此，酸性α-D-甘露糖苷酶活性似乎是组织细胞增多症X和朗格汉斯细胞共有的首个生化特征。讨论了这一发现对上述肿瘤目前组织发生学理论的意义。
