Schwartz M E
Am Fam Physician. 1981 Jun;23(6):139-41.
The three histiocytosis X diseases are often initially misdiagnosed because of their frequently slow and insidious onset. Cutaneous lesions are commonly seen and are often the initial manifestation. The atypical histiocytes in all clinical types of histiocytosis X contain characteristic intracytoplasmic granules that can be seen with the electron microscope. Skin biopsy is thus a simple and rapid method for confirming the diagnosis of histiocytosis X.
三种组织细胞增多症X疾病通常最初会被误诊,因为它们的发病往往缓慢且隐匿。皮肤病变很常见,且常常是初始表现。所有临床类型的组织细胞增多症X中的非典型组织细胞都含有特征性的胞质内颗粒,这在电子显微镜下可见。因此,皮肤活检是确诊组织细胞增多症X的一种简单快速的方法。