人和小鼠对委内瑞拉脑炎（TC - 83）病毒疫苗接种的中和抗体反应。
Neutralizing antibody responses of humans and mice to vaccination with Venezuelan encephalitis (TC-83) virus.
作者信息
Fillis C A, Calisher C H
出版信息
J Clin Microbiol. 1979 Oct;10(4):544-9. doi: 10.1128/jcm.10.4.544-549.1979.
Abstract
Laboratory workers were vaccinated with Venezuelan encephalitis virus, strain TC-83. After 2 to 3 years, they were bled, and their sera were tested for neutralizing antibody to all known Venezuelan encephalitis subtypes and varieties. The results indicated higher titers to epizootic than to enzootic Venezuelan encephalitis viruses and suggested that individuals vaccinated with TC-83 do not produce significant neutralizing antibody to heterologous subtypes. Mice vaccinated, bled, and tested in a similar manner produced much the same antibody profiles as did the humans and resisted challenge with all Venezuelan encephalitis viruses tested. In addition, the serum dilution plaque reduction neutralization test used was shown to be highly specific and adequate for diagnosis of infections with Venezuelan encephalitis viruses.
摘要
实验室工作人员接种了委内瑞拉马脑炎病毒TC - 83株。2至3年后，采集他们的血液，检测其血清中针对所有已知委内瑞拉马脑炎亚型和变种的中和抗体。结果表明，流行型委内瑞拉马脑炎病毒的抗体效价比地方流行性病毒的更高，这表明接种TC - 83的个体不会产生针对异源亚型的显著中和抗体。以类似方式接种、采血并检测的小鼠产生的抗体谱与人类大致相同，并能抵抗所检测的所有委内瑞拉马脑炎病毒的攻击。此外，所使用的血清稀释蚀斑减少中和试验被证明具有高度特异性，足以诊断委内瑞拉马脑炎病毒感染。
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