Fomufod A
Afr J Med Med Sci. 1977 Mar;6(1):7-13.
The concept of idiopathic respiratory distress syndrome (RDS) as a disease of multiple etiology has shifted during the past decade to that of a developmental biochemical dysfunctional state which has a distinct pattern of clinical expression. Knowledge of the biosynthetic processes of physiologic lung maturation together with the now available perinatal technology have made possible laboratory analysis and quantification of surface active phospholipids, and also correlation of their concentrations with the subsequent respiratory status. Whereas prediction of the syndrome now appears well established, such is not the case with prevention although significant breakthroughs have undoubtedly occurred. It is hoped that development of simple and safe modalities of preventive intervention will follow soon in the wake of these pioneering major accomplishments.
在过去十年中，特发性呼吸窘迫综合征（RDS）作为一种多病因疾病的概念已转变为一种具有独特临床表现模式的发育性生化功能障碍状态。对生理性肺成熟生物合成过程的了解以及现有的围产期技术，使得对表面活性磷脂进行实验室分析和定量成为可能，并且能够将它们的浓度与随后的呼吸状况相关联。虽然现在似乎已经很好地确立了该综合征的预测，但预防方面并非如此，尽管无疑已经取得了重大突破。希望在这些开创性的重大成就之后，能够很快出现简单而安全的预防性干预方式。
