Hutchings Catherine J, Ünsal Serbülent, Rappas Mathieu, Barnes Matthew, Waldhoer Maria, Holland Ben, Culka Martin
Independent Consultant, Hertfordshire, UK.
Antiverse, sbarc|spark, Cardiff, UK.
Pharmacol Res Perspect. 2026 Feb;14(1):e70216. doi: 10.1002/prp2.70216.
G protein-coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody-based therapies. This review offers an overview of the therapeutic GPCR-antibody target landscape and examines the diversity within current therapeutic programs at different stages of the research and development pipeline. The progression of the GPCR-antibody pipeline demonstrates ongoing maturation, reflecting advancements that have addressed several longstanding technical challenges. Additionally, we discuss the rapid expansion of artificial intelligence and machine learning platforms designed to accelerate antibody discovery and clinical development, providing specific examples of their application to GPCRs.
