筒箭毒碱对抑制性氨基酸作用的拮抗作用。
Antagonism of inhibitory amino acid action by tubocurarine.
作者信息
Curtis D R, Game C J, McCulloch R M
出版信息
Br J Pharmacol. 1974 Sep;52(1):101-3. doi: 10.1111/j.1476-5381.1974.tb09693.x.
Abstract
A comparison has been made of the antagonism by microelectrophoretically administered (+)-tubocurarine, bicuculline methochloride and strychnine of the inhibition of spinal interneurones and Renshaw cells in the cat by glycine and gamma-aminobutyric acid. The results indicate that (+)-tubocurarine would be of little use in assessing which of these amino acids was the transmitter at central inhibitory synapses.
摘要
已对微电泳给予的（+）-筒箭毒碱、氯化甲酰荷包牡丹碱和士的宁对甘氨酸和γ-氨基丁酸抑制猫脊髓中间神经元和闰绍细胞的拮抗作用进行了比较。结果表明，（+）-筒箭毒碱在评估这些氨基酸中哪一种是中枢抑制性突触的递质方面用处不大。
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Br J Pharmacol. 1978 Jan;62(1):99-106. doi: 10.1111/j.1476-5381.1978.tb07011.x.
本文引用的文献
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Amino acid antagonists and the depression of cuneate neurones by -aminobutyric acid (GABA) and glycine.氨基酸拮抗剂以及γ-氨基丁酸（GABA）和甘氨酸对楔状神经元的抑制作用。
Br J Pharmacol. 1973 Mar;47(3):642P-643P.
2
A method for comparing the potencies of -aminobutyric acid antagonists on single cortical neurones using micro-iontophoretic techniques.一种使用微离子电泳技术比较γ-氨基丁酸拮抗剂对单个皮层神经元作用强度的方法。
Br J Pharmacol. 1973 May;48(1):1-11. doi: 10.1111/j.1476-5381.1973.tb08216.x.
3
Convulsive properties of d-tubocurarine and cortical inhibition.d-筒箭毒碱的惊厥特性与皮质抑制
Nature. 1972 Nov 3;240(5375):51-2. doi: 10.1038/240051a0.
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Bicuculline methochloride as a GABA antagonist.甲基荷包牡丹碱作为一种γ-氨基丁酸拮抗剂。
Nat New Biol. 1972 Dec 13;240(102):219-20. doi: 10.1038/newbio240219a0.
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Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.荷包牡丹碱，一种γ-氨基丁酸拮抗剂，可抑制猫脊髓中的突触。
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