Leonard J M, McGee Z A, Alford R H
Arch Intern Med. 1978 Feb;138(2):201-5.
Infections caused by gentamicin sulfate-resistant Pseudomonas aeruginosa and Serratia marcescens have occurred in multiple areas of our hospitals and have caused serious clinical illness and death. Isolates of Pseudomonas organisms were sensitive to some alternative drugs including collstin sulfate, but isolates of Serratia organisms were often resistant to all commercially available parenteral antimicrobiais. All isolates were inhibited by amikacin sulfate, and 95% were killed by concentrations achievable in serum with recommended doses. Twenty patients with hospital-acquired infections, including ten with septicemia, were treated with amikacin. Eighteen of the 20 patients had a good clinical and bacteriologic response. Ototoxicity and nephrotoxicity each occurred in one patient.
由耐硫酸庆大霉素的铜绿假单胞菌和粘质沙雷氏菌引起的感染已在我们医院的多个区域发生，并导致了严重的临床疾病和死亡。铜绿假单胞菌分离株对包括硫酸多粘菌素在内的一些替代药物敏感，但粘质沙雷氏菌分离株通常对所有市售的胃肠外抗菌药物耐药。所有分离株均被硫酸阿米卡星抑制，95% 的分离株在推荐剂量下血清中可达到的浓度能将其杀灭。20 例医院获得性感染患者，包括 10 例败血症患者，接受了阿米卡星治疗。20 例患者中有 18 例有良好的临床和细菌学反应。耳毒性和肾毒性各发生在 1 例患者身上。
