粘质沙雷氏菌临床分离株对新型头孢菌素单独及与各种氨基糖苷类联合使用时的敏感性比较。
Comparative susceptibilities of clinical isolates of Serratia marcescens to newer cephalosporins, alone and in combination with various aminoglycosides.
作者信息
Markowitz S M, Sibilla D J
出版信息
Antimicrob Agents Chemother. 1980 Nov;18(5):651-5. doi: 10.1128/AAC.18.5.651.
Abstract
We examined 100 clinically significant isolates of Serratia marcescens for susceptibility to newer cephalosporin and cephamycin antibiotics, alone and in combination with various aminoglycosides. Moxalactam and cefotaxime were the most effective agents; all isolates were inhibited by 25 and 50 micrograms/ml, respectively. All strains were susceptible to amikacin at concentrations safely achievable in serum, whereas gentamicin, netilmicin, and tobramycin inhibited 63, 63, and 16% of the isolates, respectively. Moxalactam, cefotaxime, and amikacin were active against gentamicin-susceptible and gentamicin-resistant strains. Studies of synergy revealed that moxalactam and cefotaxime, in combination with netilmicin or amikacin, were often synergistic and infrequently antagonistic against cephalothin- and gentamicin-resistant strains. These results suggest that moxalactam and cefotaxime, alone or in combination, may be efficacious in treating infections due to multiply antibiotic-resistant S. marcescens.
摘要
我们检测了100株临床上具有重要意义的粘质沙雷氏菌分离株，以评估其对新型头孢菌素和头孢霉素类抗生素的敏感性，这些抗生素单独使用以及与各种氨基糖苷类抗生素联合使用时的情况。拉氧头孢和头孢噻肟是最有效的药物；所有分离株分别被25微克/毫升和50微克/毫升的浓度所抑制。所有菌株在血清中能安全达到的浓度下对阿米卡星敏感，而庆大霉素、奈替米星和妥布霉素分别抑制了63%、63%和16%的分离株。拉氧头孢、头孢噻肟和阿米卡星对庆大霉素敏感和耐药菌株均有活性。协同作用研究表明，拉氧头孢和头孢噻肟与奈替米星或阿米卡星联合使用时，对头孢噻吩和庆大霉素耐药菌株常常具有协同作用，很少产生拮抗作用。这些结果表明，拉氧头孢和头孢噻肟单独使用或联合使用，可能对治疗多重耐药粘质沙雷氏菌引起的感染有效。
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Comparative susceptibilities of clinical isolates of Serratia marcescens to newer cephalosporins, alone and in combination with various aminoglycosides.粘质沙雷氏菌临床分离株对新型头孢菌素单独及与各种氨基糖苷类联合使用时的敏感性比较。
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