Donev B
Eksp Med Morfol. 1973;12(3):165-8.
The author carried out a series of studies to discover some aspects of the mechanism of antiinflammatory action of bacterial proteolytic enzymic preparation E-30. It was established that in adrenalectomized rats the preparation inhibited to the same extent the development of carageninic edema of paws like that of the intact animals, which showed that its action was not connected with activation of hypothalamic-hypophysial-adrenal system. However, it inhibited t the activity of hyaluronidinase and diminished the permeability of the capillary walls and this could explain the strong antiexudative action, which the enzymic preparation possesses. In experiments on isolated intestines of rats and guinea pigs and on blood pressure of rats the author found that E-30 had moderate antihistaminic and antiserotonic action, which appeared to another important element in the complex mechanism, by which the preparation realized its antiinflammatory action.
作者进行了一系列研究，以发现细菌蛋白水解酶制剂E - 30抗炎作用机制的某些方面。已确定，在肾上腺切除的大鼠中，该制剂抑制爪部角叉菜胶性水肿发展的程度与完整动物相同，这表明其作用与下丘脑 - 垂体 - 肾上腺系统的激活无关。然而，它抑制了透明质酸酶的活性并降低了毛细血管壁的通透性，这可以解释该酶制剂所具有的强烈抗渗出作用。在对大鼠和豚鼠的离体肠以及大鼠血压的实验中，作者发现E - 30具有适度的抗组胺和抗5 - 羟色胺作用，这似乎是该制剂实现其抗炎作用的复杂机制中的另一个重要因素。
