Tarayre J P, Lauressergues H
Arzneimittelforschung. 1977;27(6):1144-9.
The action of a combination of chymotrypsin-trypsin + flavonoids + ascorbic acid (zymolean) has been compared with that of 7 non-steroid anti-inflammatory substances in 4 tests: a histamine induced wheal, dextran and carrageenin induced edemas, and permeability to Evans blue in the peritoneal cavity. 1. The non-steroid anti-inflammatory substances, which reduce markedly the carrageenin induced edema, are active against peritoneal permeability, but bring about almost no decrease in the effects of histamine and dextran. 2. The combination studied is effective in all of the techniques. 3. The reduction of capillary permeability induced by histamine is due to the action of flavonoids and ascorbic acid. 4. The action of the proteolytic enzymes, administered by duodenal route, on the one hand, and that of hesperidin-methylchalcone + methyl-4-esculetol + ascorbic acid on the other, accumulate to reduce the two types of edema. 5. The effect against permeability in the peritoneum seems to exerted by the combination of the flavonoids + ascorbic acid. 6. The combination studied, therefore, shows a more complete spectrum of action than the non-steroid anti-inflammatory substances against initial symptoms of inflammation.
在四项试验中，已将胰凝乳蛋白酶 - 胰蛋白酶 + 类黄酮 + 抗坏血酸（zymolean）的组合作用与7种非甾体抗炎物质的作用进行了比较：组胺诱导的风团、右旋糖酐和角叉菜胶诱导的水肿以及腹腔对伊文思蓝的通透性。1. 能显著减轻角叉菜胶诱导水肿的非甾体抗炎物质对腹腔通透性有作用，但对组胺和右旋糖酐的作用几乎没有降低。2. 所研究的组合在所有技术中均有效。3. 组胺诱导的毛细血管通透性降低是由于类黄酮和抗坏血酸的作用。4. 通过十二指肠途径给药的蛋白水解酶的作用，一方面，与橙皮苷 - 甲基查耳酮 + 甲基 - 4 - 七叶亭醇 + 抗坏血酸的作用，另一方面，累加起来可减轻两种类型的水肿。5.抗腹膜通透性的作用似乎是由类黄酮 + 抗坏血酸的组合发挥的。6. 因此，所研究的组合比非甾体抗炎物质对炎症初始症状显示出更完整的作用谱。
