Labovitz E, Levison M E, Kaye D
Antimicrob Agents Chemother. 1974 Oct;6(4):465-70. doi: 10.1128/AAC.6.4.465.
Patients with urinary tract infection were treated for 8 to 15 days with one daily intramuscular injection of 160 mg of gentamicin or 60 or 80 mg every 8 h. Ten of 11 patients treated with one injection daily were cured as compared with 8 of 10 patients treated with three injections daily. Urinary concentrations of gentamicin were 3.2 to 600 mug/ml in all 8-h collections in patients receiving one injection daily and were 22 to 440 mug/ml in all 8-h collections in patients receiving three injections daily. The group treated once daily demonstrated a significant but reversible increase in mean serum creatinine concentration and decrease in mean creatinine clearance during therapy as compared with no change in the group treated with three injections daily. Decreases in renal function were correlated with higher milligram per kilogram doses and higher 1-h serum concentrations.
患有尿路感染的患者接受了8至15天的治疗，每日一次肌肉注射160毫克庆大霉素，或每8小时注射60或80毫克。每日注射一次的11名患者中有10名治愈，而每日注射三次的10名患者中有8名治愈。每日注射一次的患者在所有8小时收集样本中的庆大霉素尿液浓度为3.2至600微克/毫升，每日注射三次的患者在所有8小时收集样本中的庆大霉素尿液浓度为22至440微克/毫升。与每日注射三次的组无变化相比，每日注射一次的组在治疗期间平均血清肌酐浓度显著但可逆地升高，平均肌酐清除率降低。肾功能下降与每千克更高的毫克剂量和更高的1小时血清浓度相关。
