Madsen P O, Kjaer T B, Mosegaard A
Urology. 1977 Jun;9(6):635-8. doi: 10.1016/0090-4295(77)90309-0.
The efficacy and safety of the two aminoglycoside antibiotics, sisomicin and gentamicin, were investigated in a prospective randomized study of 100 elderly male patients with complicated urinary tract infections. Both drugs were administered intramuscularly, sisomicin twice daily and gentamicin three times daily according to body weight. All bacteria isolated from the urine were sensitive to both antibiotics by disk sensitivity method. Seventy per cent of the patients treated with sisomicn and 63 per cent of those treated with gentamicin were cured of infection. There was no apparent toxicity noted from either drug. The twice daily sisomicin administration appeared to be as effective and safe as the three times daily administration of gentamicin in the treatment of complicated urinary tract infections.
在一项针对100名患有复杂性尿路感染的老年男性患者的前瞻性随机研究中，对两种氨基糖苷类抗生素西索米星和庆大霉素的疗效及安全性进行了调查。两种药物均通过肌肉注射给药，西索米星根据体重每日注射两次，庆大霉素每日注射三次。通过纸片扩散法检测，从尿液中分离出的所有细菌对这两种抗生素均敏感。接受西索米星治疗的患者中有70%感染治愈，接受庆大霉素治疗的患者中有63%感染治愈。两种药物均未发现明显毒性。在治疗复杂性尿路感染方面，每日两次注射西索米星似乎与每日三次注射庆大霉素一样有效且安全。
