Corry W D, Meiselman H J
Blood. 1978 Apr;51(4):693-701.
A recently developed technique for deforming red blood cells (RBC) in which they are centrifuged through buffer and into a glutaraldehyde solution was evaluated as a method of assessing cellular deformability (i.e., the ability of the entire RBC to form a new configuration). To accomplish this, RBC populations of differing cellular deformability were tested, using three generally accepted techniques to obtain these differences: partial fixation with low concentrations of glutaraldehyde, density fractionation, and suspension of RBC in nonisotonic media. Our results indicate that at a constant deforming force the mean deformed length of the RBC decreased under conditions where cellular deformability is known to decrease, thus suggesting the usefulness of this centrifugal method for the estimation of this cellular property.
一种最近开发的使红细胞（RBC）变形的技术，即让红细胞通过缓冲液离心进入戊二醛溶液，被评估为一种评估细胞变形能力（即整个红细胞形成新形态的能力）的方法。为实现这一点，对具有不同细胞变形能力的红细胞群体进行了测试，采用了三种普遍认可的获得这些差异的技术：用低浓度戊二醛进行部分固定、密度分级分离以及将红细胞悬浮于非等渗介质中。我们的结果表明，在恒定的变形力下，已知细胞变形能力降低的条件下，红细胞的平均变形长度会减小，从而表明这种离心方法对于评估这种细胞特性是有用的。
