大鼠体内γ-2,3,4,5,6-五氯环己-1-烯和γ-六氯环己烷的代谢
The metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and gamma-hexachlorocyclohexane in rats.
作者信息
Grover P L, Sims P
出版信息
Biochem J. 1965 Aug;96(2):521-5. doi: 10.1042/bj0960521.
Abstract
- After intraperitoneal administration, gamma-hexachlorocyclohexane (Gammexane) and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of gamma-hexachlorocyclohexane and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in gamma-hexachlorocyclohexane metabolism in rats.
摘要
- 腹腔注射后，大鼠将γ-六氯环己烷（林丹）和γ-2,3,4,5,6-五氯环己-1-烯转化为2,3,5-和2,4,5-三氯苯酚，这些物质以游离酚以及硫酸和葡萄糖醛酸结合物的形式排出。2. 从尿液中分离出2,4,5-三氯苯酚、2,4,5-三氯苯基葡萄糖醛酸苷和2,4-二氯苯基巯基尿酸的衍生物，作为γ-2,3,4,5,6-五氯环己-1-烯的代谢产物。3. 从尿液中分离出的γ-六氯环己烷和γ-2,3,4,5,6-五氯环己-1-烯的酚类代谢产物与1,2,4-三氯苯的类似，这表明后两种化合物是大鼠体内γ-六氯环己烷代谢的中间产物。
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本文引用的文献
1
Tissue distribution, accumulation and elimination of the isomers of benzene hexachloride.六氯环己烷异构体的组织分布、蓄积与消除
Proc Soc Exp Biol Med. 1951 Apr;76(4):780-3. doi: 10.3181/00379727-76-18631.
2
Studies in detoxication. 37. Metabolism of benzene: examination of the glucuronide fraction of rabbit urine after administration of benzene; isolation of phenylglucuronide.解毒研究。37. 苯的代谢：给兔子注射苯后对其尿液中葡萄糖醛酸苷部分的检测；苯葡萄糖醛酸苷的分离。
Biochem J. 1951 May;48(5):621-4. doi: 10.1042/bj0480621.
3
Studies in detoxication. 63. The metabolism of halogenobenzenes; (a) meta-dichlorobenzene (b) further observations on the metabolism of chlorobenzene.解毒研究。63. 卤代苯的代谢；(a) 间二氯苯 (b) 关于氯苯代谢的进一步观察
Biochem J. 1955 Mar;59(3):415-22. doi: 10.1042/bj0590415.
4
CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES.与谷胱甘肽的结合。某些氯代环己烯的酶促结合
Biochem J. 1965 Apr;95(1):156-60. doi: 10.1042/bj0950156.
5
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Nature. 1959 Apr 4;183(4666):983-4. doi: 10.1038/183983b0.
6
Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.有毒物质的生化研究。11. 巯基尿酸前体的存在情况。
Biochem J. 1958 Sep;70(1):111-9. doi: 10.1042/bj0700111.
7
Studies in detoxication. 66. The metabolism of halogenobenzenes: 1:2:3-, 1:2:4- and 1:3:5-trichlorobenzenes.解毒研究。66. 卤代苯的代谢：1:2:3-、1:2:4-和1:3:5-三氯苯
Biochem J. 1955 Nov;61(3):512-21. doi: 10.1042/bj0610512.
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