酚酞和二元羧酸对谷胱甘肽S-芳基转移酶抑制作用的种属差异。
Species differences in the inhibition of glutathione S-aryltransferase by phthaleins and dicarboxylic acids.
作者信息
Clark A G, Darby F J, Smith J N
出版信息
Biochem J. 1967 Apr;103(1):49-54. doi: 10.1042/bj1030049.
Abstract
- Glutathione-S-aryltransferase activity from grass grubs (Costelytra zealandica) was inhibited by phthaleins, sulphonphthaleins and some dicarboxylic acids. 2. These compounds had no detectable action on the enzyme from sheep liver. 3. In insect enzyme the inhibition was competitive with respect to glutathione and non-competitive with respect to the aromatic substrate. 4. Michaelis constants and inhibitor constants were measured for sheep-liver or grass-grub enzyme between pH5 and pH10 and evidence was obtained for the presence of two groups with pK9.2 in the glutathione-binding site of the insect enzyme. 5. Only one such group was detected in the sheep-liver enzyme.
摘要
- 酞类、磺酞类和一些二羧酸可抑制牧草金龟子（新西兰肋翅鳃金龟）的谷胱甘肽-S-芳基转移酶活性。2. 这些化合物对绵羊肝脏中的该酶未表现出可检测到的作用。3. 在昆虫酶中，这种抑制作用对谷胱甘肽而言是竞争性的，对芳香底物而言是非竞争性的。4. 在pH5至pH10之间测定了绵羊肝脏或牧草金龟子酶的米氏常数和抑制剂常数，并获得证据表明昆虫酶的谷胱甘肽结合位点存在两个pK为9.2的基团。5. 在绵羊肝脏酶中仅检测到一个这样的基团。
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