Scott M T
Dev Biol Stand. 1977;38:273-6.
Accumulated data suggest that one of two antitumour mechanisms of C. parvum may predominate depending on the route of injection of C. parvum and its distribution in relation to the tumour. After systemic C. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by C. parvum activated macrophages. After local injection of C. parvum the interaction (direct or lymph node mediated) between C. parvum and tumour specific antigens has resulted in the generation of immunologically specific T-lymphocytes with antitumour activity.
积累的数据表明，根据微小隐孢子虫的注射途径及其与肿瘤的分布关系，微小隐孢子虫的两种抗肿瘤机制之一可能占主导地位。在全身注射微小隐孢子虫后，该机制被认为是免疫非特异性的（即不需要肿瘤特异性抗原），并由微小隐孢子虫激活的巨噬细胞介导。在局部注射微小隐孢子虫后，微小隐孢子虫与肿瘤特异性抗原之间的相互作用（直接或通过淋巴结介导）导致产生具有抗肿瘤活性的免疫特异性T淋巴细胞。
