McBride W H, Peters L J, Mason K A, Milas L
Dev Biol Stand. 1977;38:253-7.
The frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (Fsa) was not influenced by systemic administration of C. parvum (day + 3) except when doses less than the TD50 were injected. Then the number of takes was increased. The tumour normally grows progressively however regression was frequent in intact mice treated with C. parvum. Tumour regression did not occur in T cell-depleted mice treated in the same way. Splenic T cell-enriched populations of cells taken from Fsa-bearing C. parvum-treated mice caused tumour regression when adoptively transferred to Fsa-bearing T cell-depleted mice. Although this assay measures systemic rather than intratumoral T cell activity, it is proposed that C. parvum-induced regression of the fibrosarcoma is to a large extent due to enhanced T cell reactivity.
皮下注射同基因化学诱导纤维肉瘤（Fsa）产生肿瘤的频率不受小隐孢子虫全身给药（第3天）的影响，除非注射剂量小于半数中毒剂量（TD50）。此时，接种成功的数量会增加。肿瘤通常会进行性生长，然而在用小隐孢子虫治疗的完整小鼠中，肿瘤消退很常见。以同样方式治疗的T细胞耗竭小鼠未出现肿瘤消退。从接种Fsa并经小隐孢子虫治疗的小鼠中获取的富含脾T细胞的细胞群体，当通过过继转移到接种Fsa的T细胞耗竭小鼠体内时，会导致肿瘤消退。尽管该检测方法测量的是全身而非肿瘤内的T细胞活性，但有人提出，小隐孢子虫诱导的纤维肉瘤消退在很大程度上归因于T细胞反应性增强。
