感染乳酸脱氢酶病毒的小鼠体内γ-球蛋白升高及抗体产生增加。
Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus.
作者信息
Notkins A L, Mergenhagen S E, Rizzo A A, Scheele C, Waldmann T A
出版信息
J Exp Med. 1966 Feb 1;123(2):347-64. doi: 10.1084/jem.123.2.347.
Abstract
Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.
摘要
用乳酸脱氢酶病毒（LDV）感染小鼠会导致γ-球蛋白水平升高。对脾脏和淋巴结进行组织学检查发现，生发中心的数量大幅增加。用人γ-球蛋白进行免疫显示，病毒感染动物产生抗人γ-球蛋白的能力大大增强，且该病毒起到了佐剂的作用。从这些实验得出结论，病毒感染（LDV）可影响宿主对异源抗原的免疫反应。
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本文引用的文献
1
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J Immunol. 1951 Oct;67(4):243-55.
2
The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.蛋白质在经单宁酸处理的红细胞上的吸附以及随后抗蛋白质血清引起的血细胞凝集。
J Exp Med. 1951 Feb;93(2):107-20. doi: 10.1084/jem.93.2.107.
3
Studies of a virus isolated from a wild house mouse, Mus musculus, and producing splenomegaly and lymph node enlargement in mice.
Aust J Exp Biol Med Sci. 1961 Dec;39:521-36. doi: 10.1038/icb.1961.53.
4
INFLUENCE OF OLIGODEOXYRIBONUCLEOTIDES ON EARLY EVENTS IN ANTIBODY FORMATION.寡脱氧核糖核苷酸对抗体形成早期事件的影响
Proc Soc Exp Biol Med. 1965 Jul;119:701-7. doi: 10.3181/00379727-119-30276.
5
6
ULTRASTRUCTURE OF THE LACTIC DEHYDROGENASE VIRUS (LDV) AND CELL-VIRUS RELATIONSHIPS.
Virology. 1965 Jul;26:512-6. doi: 10.1016/0042-6822(65)90017-6.
7
ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
J Exp Med. 1965 Jun 1;121(6):969-89. doi: 10.1084/jem.121.6.969.
8
LACTIC DEHYDROGENASE VIRUS.乳酸脱氢酶病毒
Bacteriol Rev. 1965 Jun;29(2):143-60. doi: 10.1128/br.29.2.143-160.1965.
9
INTRACELLULAR DISTRIBUTION AND DEGRADATION OF BACTERIOPHAGE IN MAMMALIAN TISSUES.噬菌体在哺乳动物组织中的细胞内分布与降解
J Immunol. 1965 Apr;94:544-50.
10
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