Notkins A L, Mergenhagen S E, Rizzo A A, Scheele C, Waldmann T A
J Exp Med. 1966 Feb 1;123(2):347-64. doi: 10.1084/jem.123.2.347.
Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.
用乳酸脱氢酶病毒(LDV)感染小鼠会导致γ-球蛋白水平升高。对脾脏和淋巴结进行组织学检查发现,生发中心的数量大幅增加。用人γ-球蛋白进行免疫显示,病毒感染动物产生抗人γ-球蛋白的能力大大增强,且该病毒起到了佐剂的作用。从这些实验得出结论,病毒感染(LDV)可影响宿主对异源抗原的免疫反应。