Morimoto M, Yamada M, Arizono N, Hayashi T
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
Immunology. 1998 Apr;93(4):540-5. doi: 10.1046/j.1365-2567.1998.00454.x.
The effects of lactic dehydrogenase virus (LDV) infection on the protective immune responses to the nematode Nippostrongylus brasiliensis were studied. Mice with chronic LDV infection showed significantly higher levels of parasite egg production than non-LDV-infected (control) mice after N. brasiliensis infection. Concurrent LDV infection also suppressed peripheral blood eosinophilia and the lung mastocytosis induced by this nematode. LDV infection showed higher expression levels of the interferon-gamma (IFN-gamma) mRNA in lymph nodes compared with control mice before N. brasiliensis infection. In addition, the IgG2a production in LDV-infected mice was higher than that in control mice before and after N. brasiliensis infection. These results suggest that LDV infection modulates protective immune responses against N. brasiliensis infection by the activation of T-helper type 1 cells.
研究了乳酸脱氢酶病毒（LDV）感染对巴西日圆线虫保护性免疫反应的影响。慢性LDV感染的小鼠在感染巴西日圆线虫后，其寄生虫卵产量水平显著高于未感染LDV的（对照）小鼠。同时感染LDV也抑制了该线虫诱导的外周血嗜酸性粒细胞增多和肺肥大细胞增多。在感染巴西日圆线虫之前，与对照小鼠相比，LDV感染的小鼠淋巴结中干扰素-γ（IFN-γ）mRNA表达水平更高。此外，在感染巴西日圆线虫前后，LDV感染小鼠的IgG2a产量均高于对照小鼠。这些结果表明，LDV感染通过激活1型辅助性T细胞来调节针对巴西日圆线虫感染的保护性免疫反应。
