Till G, Rother U, Gemsa D
Int Arch Allergy Appl Immunol. 1978;56(6):543-50. doi: 10.1159/000232070.
Iodinated radiographic contrast media such as methylglucamine diatrizoate and sodium ioglycamate activate serum complement in vitro. This was shown by a dose-, time-, and temperature-dependent decrease of total hemolytic complement activity in normal human serum, consumption of C4 and C6 activity, conversion of C3 to C3b, and generation of C5-derived chemotactic and smooth muscle contracting activity. Complement activation was achieved even in sera depleted of immunoglobulin and properdin, which may indicate that contrast media induce complement activation by mechanisms different from the classical or alternative pathway.
碘化造影剂，如泛影葡胺和碘甘氨酸钠，在体外可激活血清补体。正常人类血清中总溶血补体活性呈剂量、时间和温度依赖性降低，C4和C6活性消耗，C3转化为C3b，以及产生C5衍生的趋化活性和平滑肌收缩活性，均表明了这一点。即使在缺乏免疫球蛋白和备解素的血清中也能实现补体激活，这可能表明造影剂通过不同于经典或替代途径的机制诱导补体激活。
